Antral follice counts (AFC) predict ovarian response and pregnancy outcomes in oocyte donation cycles

Purpose: Antral follicle count (AFC) is used as a marker of ovarian response. We assessed its value in predicting pregnancy outcomes in ovum donation cycles by retrospective review. Methods: Oocyte donors (n=94) underwent ovarian hyperstimulation using rFSH and GnRH-antagonists. Recipients were synchronized using GnRH-agonist down-regulation followed by fixed dose of estrogen and progesterone following hCG. Outcomes measured included correlation of AFC to pregnancy outcomes and cycle characteristics in those with and without clinical and ongoing-delivered cycles. Results: AFC significantly correlated with clinical [Exp β 1.12; 95% CI: 1.02-1.23, p<0.05] and ongoing-delivered pregnancy [Exp β 1.10; 95% CI: 1.01-1.20, p<0.05]. Significantly greater AFC, total and M-2 oocytes, and cycles resulting in cryopreserved embryos were seen in clinical and ongoing-delivered cycles. Conclusions: AFC predicts cycle stimulation responses and clinical outcomes and may serve as a guide for dosing protocols and in choosing to proceed with the most optimal cycle.