Antiviral immune response in patients with multiple sclerosis and healthy siblings

M. Comabella; X. Montalban; A. Horga; B. Messmer; K. Kakalacheva; T. Strowig; E. Caballero; C. Münz; J. D. Lünemann

doi:10.1177/1352458509357066

Antiviral immune response in patients with multiple sclerosis and healthy siblings

M. Comabella, X. Montalban, A. Horga, B. Messmer, K. Kakalacheva, T. Strowig, E. Caballero, C. Münz, J. D. Lünemann

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The objective of this study was to determine the immune responses to candidate viral triggers of multiple sclerosis in patients and healthy siblings raised in the same family household. Virus antigen-specific IgG responses to Epstein-Barr virus-derived gene products as well as to human herpersvirus-6, human cytomegalovirus, and measles virus were evaluated in 25 multiple sclerosis patients and compared with 49 healthy full-siblings. IgG responses to the latent Epstein-Barr virus-encoded nuclear antigen-1 (EBNA1) were selectively increased in individuals with multiple sclerosis compared with their unaffected siblings. We conclude that elevated IgG responses towards EBNA1 are associated with the development of multiple sclerosis.

Original language	English
Pages (from-to)	355-358
Number of pages	4
Journal	Multiple Sclerosis Journal
Volume	16
Issue number	3
DOIs	https://doi.org/10.1177/1352458509357066
State	Published - Mar 2010
Externally published	Yes

Keywords

EBV-encoded nuclear antigen-1
EBV-viral capsid antigen
Environmental factors
Epstein-Barr virus
Immune responses
Multiple sclerosis

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10.1177/1352458509357066

Cite this

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abstract = "The objective of this study was to determine the immune responses to candidate viral triggers of multiple sclerosis in patients and healthy siblings raised in the same family household. Virus antigen-specific IgG responses to Epstein-Barr virus-derived gene products as well as to human herpersvirus-6, human cytomegalovirus, and measles virus were evaluated in 25 multiple sclerosis patients and compared with 49 healthy full-siblings. IgG responses to the latent Epstein-Barr virus-encoded nuclear antigen-1 (EBNA1) were selectively increased in individuals with multiple sclerosis compared with their unaffected siblings. We conclude that elevated IgG responses towards EBNA1 are associated with the development of multiple sclerosis.",

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AU - Comabella, M.

AU - Montalban, X.

AU - Horga, A.

AU - Messmer, B.

AU - Kakalacheva, K.

AU - Strowig, T.

AU - Caballero, E.

AU - Münz, C.

AU - Lünemann, J. D.

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AB - The objective of this study was to determine the immune responses to candidate viral triggers of multiple sclerosis in patients and healthy siblings raised in the same family household. Virus antigen-specific IgG responses to Epstein-Barr virus-derived gene products as well as to human herpersvirus-6, human cytomegalovirus, and measles virus were evaluated in 25 multiple sclerosis patients and compared with 49 healthy full-siblings. IgG responses to the latent Epstein-Barr virus-encoded nuclear antigen-1 (EBNA1) were selectively increased in individuals with multiple sclerosis compared with their unaffected siblings. We conclude that elevated IgG responses towards EBNA1 are associated with the development of multiple sclerosis.

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Antiviral immune response in patients with multiple sclerosis and healthy siblings

Abstract

Keywords

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