Antitumor activity of nifurtimox observed in a patient with neuroblastoma

Giselle L. Saulnier Sholler; Satyan Kalkunte; Carla Greenlaw; Kathleen McCarten; Edwin Forman

doi:10.1097/01.mph.0000212994.56812.f2

Antitumor activity of nifurtimox observed in a patient with neuroblastoma

Giselle L. Saulnier Sholler, Satyan Kalkunte, Carla Greenlaw, Kathleen McCarten, Edwin Forman

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

BACKGROUND: Chemotherapy-resistant neuroblastoma is a difficult disease to treat with poor survival. OBSERVATIONS: We treated a patient with neuroblastoma who had progressed on conventional chemotherapy. This 5-year-old girl with chemotherapy-resistant neuroblastoma developed Chagas disease at the start of salvage chemotherapy for which she was also started on nifurtimox. The neuroblastoma response to these treatments resulted in clinical remission. In vitro, treatment of a neuroblastoma cell line with nifurtimox resulted in decreased cell viability whereas no effect was seen on an endothelial cell line. CONCLUSIONS: Nifurtimox shows promise as a potential new treatment for neuroblastoma and warrants further testing.

Original language	English
Pages (from-to)	693-695
Number of pages	3
Journal	Journal of Pediatric Hematology/Oncology
Volume	28
Issue number	10
DOIs	https://doi.org/10.1097/01.mph.0000212994.56812.f2
State	Published - Oct 2006
Externally published	Yes

Keywords

Neuroblastoma
Nifurtimox
Treatment

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title = "Antitumor activity of nifurtimox observed in a patient with neuroblastoma",

abstract = "BACKGROUND: Chemotherapy-resistant neuroblastoma is a difficult disease to treat with poor survival. OBSERVATIONS: We treated a patient with neuroblastoma who had progressed on conventional chemotherapy. This 5-year-old girl with chemotherapy-resistant neuroblastoma developed Chagas disease at the start of salvage chemotherapy for which she was also started on nifurtimox. The neuroblastoma response to these treatments resulted in clinical remission. In vitro, treatment of a neuroblastoma cell line with nifurtimox resulted in decreased cell viability whereas no effect was seen on an endothelial cell line. CONCLUSIONS: Nifurtimox shows promise as a potential new treatment for neuroblastoma and warrants further testing.",

keywords = "Neuroblastoma, Nifurtimox, Treatment",

author = "{Saulnier Sholler}, {Giselle L.} and Satyan Kalkunte and Carla Greenlaw and Kathleen McCarten and Edwin Forman",

year = "2006",

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doi = "10.1097/01.mph.0000212994.56812.f2",

language = "English",

volume = "28",

pages = "693--695",

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T1 - Antitumor activity of nifurtimox observed in a patient with neuroblastoma

AU - Saulnier Sholler, Giselle L.

AU - Kalkunte, Satyan

AU - Greenlaw, Carla

AU - McCarten, Kathleen

AU - Forman, Edwin

PY - 2006/10

Y1 - 2006/10

N2 - BACKGROUND: Chemotherapy-resistant neuroblastoma is a difficult disease to treat with poor survival. OBSERVATIONS: We treated a patient with neuroblastoma who had progressed on conventional chemotherapy. This 5-year-old girl with chemotherapy-resistant neuroblastoma developed Chagas disease at the start of salvage chemotherapy for which she was also started on nifurtimox. The neuroblastoma response to these treatments resulted in clinical remission. In vitro, treatment of a neuroblastoma cell line with nifurtimox resulted in decreased cell viability whereas no effect was seen on an endothelial cell line. CONCLUSIONS: Nifurtimox shows promise as a potential new treatment for neuroblastoma and warrants further testing.

AB - BACKGROUND: Chemotherapy-resistant neuroblastoma is a difficult disease to treat with poor survival. OBSERVATIONS: We treated a patient with neuroblastoma who had progressed on conventional chemotherapy. This 5-year-old girl with chemotherapy-resistant neuroblastoma developed Chagas disease at the start of salvage chemotherapy for which she was also started on nifurtimox. The neuroblastoma response to these treatments resulted in clinical remission. In vitro, treatment of a neuroblastoma cell line with nifurtimox resulted in decreased cell viability whereas no effect was seen on an endothelial cell line. CONCLUSIONS: Nifurtimox shows promise as a potential new treatment for neuroblastoma and warrants further testing.

KW - Neuroblastoma

KW - Nifurtimox

KW - Treatment

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Antitumor activity of nifurtimox observed in a patient with neuroblastoma

Abstract

Keywords

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