Antithrombotic treatment strategies in patients with established coronary atherosclerotic disease

Marco Valgimigli; Victor Aboyans; Dominick Angiolillo; Dan Atar; Davide Capodanno; Sigrun Halvorsen; Stefan James; Peter Jüni; Vijay Kunadian; Antonio Landi; Sergio Leonardi; Roxana Mehran; Gilles Montalescot; Eliano Pio Navarese; Josef Niebauer; Angelo Oliva; Raffaele Piccolo; Susanna Price; Robert F. Storey; Heinz Völler; Pascal Vranckx; Stephan Windecker; Keith A.A. Fox

doi:10.1093/ehjcvp/pvad032

Antithrombotic treatment strategies in patients with established coronary atherosclerotic disease

Marco Valgimigli, Victor Aboyans, Dominick Angiolillo, Dan Atar, Davide Capodanno, Sigrun Halvorsen, Stefan James, Peter Jüni, Vijay Kunadian, Antonio Landi, Sergio Leonardi, Roxana Mehran, Gilles Montalescot, Eliano Pio Navarese, Josef Niebauer, Angelo Oliva, Raffaele Piccolo, Susanna Price, Robert F. Storey, Heinz VöllerPascal Vranckx, Stephan Windecker, Keith A.A. Fox

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39 Scopus citations

Abstract

Multiple guidelines and consensus papers have addressed the role of antithrombotic strategies in patients with established coronary artery disease (CAD). Since evidence and terminology continue to evolve, the authors undertook a consensus initiative to guide clinicians to select the optimal antithrombotic regimen for each patient. The aim of this document is to provide an update for clinicians on best antithrombotic strategies in patients with established CAD, classifying each treatment option in relation to the number of antithrombotic drugs irrespective of whether the traditional mechanism of action is expected to mainly inhibit platelets or coagulation cascade. With the aim to reach comprehensiveness of available evidence, we systematically reviewed and performed meta-analyses by means of both direct and indirect comparisons to inform the present consensus document.

Original language	English
Pages (from-to)	462-496
Number of pages	35
Journal	European Heart Journal - Cardiovascular Pharmacotherapy
Volume	9
Issue number	5
DOIs	https://doi.org/10.1093/ehjcvp/pvad032
State	Published - 1 Aug 2023

Keywords

Acute coronary syndrome
Antithrombotic treatment
Chronic coronary syndrome
Coronary artery disease
Percutaneous coronary intervention

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10.1093/ehjcvp/pvad032

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Valgimigli, M., Aboyans, V., Angiolillo, D., Atar, D., Capodanno, D., Halvorsen, S., James, S., Jüni, P., Kunadian, V., Landi, A., Leonardi, S., Mehran, R., Montalescot, G., Navarese, E. P., Niebauer, J., Oliva, A., Piccolo, R., Price, S., Storey, R. F., ... Fox, K. A. A. (2023). Antithrombotic treatment strategies in patients with established coronary atherosclerotic disease. European Heart Journal - Cardiovascular Pharmacotherapy, 9(5), 462-496. https://doi.org/10.1093/ehjcvp/pvad032

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title = "Antithrombotic treatment strategies in patients with established coronary atherosclerotic disease",

abstract = "Multiple guidelines and consensus papers have addressed the role of antithrombotic strategies in patients with established coronary artery disease (CAD). Since evidence and terminology continue to evolve, the authors undertook a consensus initiative to guide clinicians to select the optimal antithrombotic regimen for each patient. The aim of this document is to provide an update for clinicians on best antithrombotic strategies in patients with established CAD, classifying each treatment option in relation to the number of antithrombotic drugs irrespective of whether the traditional mechanism of action is expected to mainly inhibit platelets or coagulation cascade. With the aim to reach comprehensiveness of available evidence, we systematically reviewed and performed meta-analyses by means of both direct and indirect comparisons to inform the present consensus document.",

keywords = "Acute coronary syndrome, Antithrombotic treatment, Chronic coronary syndrome, Coronary artery disease, Percutaneous coronary intervention",

author = "Marco Valgimigli and Victor Aboyans and Dominick Angiolillo and Dan Atar and Davide Capodanno and Sigrun Halvorsen and Stefan James and Peter J{\"u}ni and Vijay Kunadian and Antonio Landi and Sergio Leonardi and Roxana Mehran and Gilles Montalescot and Navarese, {Eliano Pio} and Josef Niebauer and Angelo Oliva and Raffaele Piccolo and Susanna Price and Storey, {Robert F.} and Heinz V{\"o}ller and Pascal Vranckx and Stephan Windecker and Fox, {Keith A.A.}",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s). Published by Oxford University Press on behalf of the European Society of Cardiology.",

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doi = "10.1093/ehjcvp/pvad032",

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Valgimigli, M, Aboyans, V, Angiolillo, D, Atar, D, Capodanno, D, Halvorsen, S, James, S, Jüni, P, Kunadian, V, Landi, A, Leonardi, S, Mehran, R, Montalescot, G, Navarese, EP, Niebauer, J, Oliva, A, Piccolo, R, Price, S, Storey, RF, Völler, H, Vranckx, P, Windecker, S & Fox, KAA 2023, 'Antithrombotic treatment strategies in patients with established coronary atherosclerotic disease', European Heart Journal - Cardiovascular Pharmacotherapy, vol. 9, no. 5, pp. 462-496. https://doi.org/10.1093/ehjcvp/pvad032

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T1 - Antithrombotic treatment strategies in patients with established coronary atherosclerotic disease

AU - Valgimigli, Marco

AU - Aboyans, Victor

AU - Angiolillo, Dominick

AU - Atar, Dan

AU - Capodanno, Davide

AU - Halvorsen, Sigrun

AU - James, Stefan

AU - Jüni, Peter

AU - Kunadian, Vijay

AU - Landi, Antonio

AU - Leonardi, Sergio

AU - Mehran, Roxana

AU - Montalescot, Gilles

AU - Navarese, Eliano Pio

AU - Niebauer, Josef

AU - Oliva, Angelo

AU - Piccolo, Raffaele

AU - Price, Susanna

AU - Storey, Robert F.

AU - Völler, Heinz

AU - Vranckx, Pascal

AU - Windecker, Stephan

AU - Fox, Keith A.A.

PY - 2023/8/1

Y1 - 2023/8/1

N2 - Multiple guidelines and consensus papers have addressed the role of antithrombotic strategies in patients with established coronary artery disease (CAD). Since evidence and terminology continue to evolve, the authors undertook a consensus initiative to guide clinicians to select the optimal antithrombotic regimen for each patient. The aim of this document is to provide an update for clinicians on best antithrombotic strategies in patients with established CAD, classifying each treatment option in relation to the number of antithrombotic drugs irrespective of whether the traditional mechanism of action is expected to mainly inhibit platelets or coagulation cascade. With the aim to reach comprehensiveness of available evidence, we systematically reviewed and performed meta-analyses by means of both direct and indirect comparisons to inform the present consensus document.

AB - Multiple guidelines and consensus papers have addressed the role of antithrombotic strategies in patients with established coronary artery disease (CAD). Since evidence and terminology continue to evolve, the authors undertook a consensus initiative to guide clinicians to select the optimal antithrombotic regimen for each patient. The aim of this document is to provide an update for clinicians on best antithrombotic strategies in patients with established CAD, classifying each treatment option in relation to the number of antithrombotic drugs irrespective of whether the traditional mechanism of action is expected to mainly inhibit platelets or coagulation cascade. With the aim to reach comprehensiveness of available evidence, we systematically reviewed and performed meta-analyses by means of both direct and indirect comparisons to inform the present consensus document.

KW - Acute coronary syndrome

KW - Antithrombotic treatment

KW - Chronic coronary syndrome

KW - Coronary artery disease

KW - Percutaneous coronary intervention

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JO - European Heart Journal - Cardiovascular Pharmacotherapy

JF - European Heart Journal - Cardiovascular Pharmacotherapy

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ER -

Antithrombotic treatment strategies in patients with established coronary atherosclerotic disease

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