Antithrombotic Therapy in Non-ST-Segment Elevation Acute Coronary Syndromes

Georgios J. Vlachojannis, Vijayalakshmi Kunadian, Joseph M. Sweeny, Roxana Mehran

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The transition from asymptomatic, nonobstructive coronary atherosclerosis to symptomatic, occlusive disease is related to atherothrombosis. The clinical presentation encompasses the entity of acute coronary syndrome. Non-ST-segment elevation acute coronary syndrome (NSTE-ACS), comprised of unstable angina and non-ST-segment myocardial infarction, poses a major public health issue. Agents that exert antithrombotic effects either by targeting platelet function or interacting with the coagulation system serve as a cornerstone in the management of ACS patients; major developments in antithrombotic therapy have led to significant improvement in clinical outcomes. This chapter describes the pathophysiology of NSTE-ACS and provides an overview of the different antithrombotic agents utilized in the management of patients with NSTE-ACS, as well as scientific evidence and supporting clinical guidelines available for each agent. The chapter rounds off with a glimpse into the future by presenting novel antithrombotic agents currently under clinical investigation.

Original languageEnglish
Title of host publicationTherapeutic Advances in Thrombosis, Second Edition
PublisherBlackwell Publishing Ltd.
Pages213-235
Number of pages23
ISBN (Print)9781405196253
DOIs
StatePublished - 3 Oct 2012

Keywords

  • Acute coronary syndrome
  • Anticoagulation
  • Antiplatelet
  • Antithrombotic
  • Non-ST-elevation acute coronary syndrome
  • Non-ST-elevation myocardial infarction
  • Therapy
  • Treatment
  • Unstable angina

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