Antithrombotic Therapy in Non-ST-Segment Elevation Acute Coronary Syndromes

Georgios J. Vlachojannis, Vijayalakshmi Kunadian, Joseph M. Sweeny, Roxana Mehran

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The transition from asymptomatic, nonobstructive coronary atherosclerosis to symptomatic, occlusive disease is related to atherothrombosis. The clinical presentation encompasses the entity of acute coronary syndrome. Non-ST-segment elevation acute coronary syndrome (NSTE-ACS), comprised of unstable angina and non-ST-segment myocardial infarction, poses a major public health issue. Agents that exert antithrombotic effects either by targeting platelet function or interacting with the coagulation system serve as a cornerstone in the management of ACS patients; major developments in antithrombotic therapy have led to significant improvement in clinical outcomes. This chapter describes the pathophysiology of NSTE-ACS and provides an overview of the different antithrombotic agents utilized in the management of patients with NSTE-ACS, as well as scientific evidence and supporting clinical guidelines available for each agent. The chapter rounds off with a glimpse into the future by presenting novel antithrombotic agents currently under clinical investigation.

Original languageEnglish
Title of host publicationTherapeutic Advances in Thrombosis, Second Edition
PublisherBlackwell Publishing Ltd.
Number of pages23
ISBN (Print)9781405196253
StatePublished - 3 Oct 2012


  • Acute coronary syndrome
  • Anticoagulation
  • Antiplatelet
  • Antithrombotic
  • Non-ST-elevation acute coronary syndrome
  • Non-ST-elevation myocardial infarction
  • Therapy
  • Treatment
  • Unstable angina


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