Antithrombotic effects of Abciximab

Richard Hayes, James H. Chesebro, Valentin Fuster, George Dangas, John T. Fallon, Samin K. Sharma, Barry S. Coller, Lina Badimon, Jonathan D. Marmur, Juan Jose Badimon

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

The observation that platelet-platelet interaction and thrombosis are ultimately regulated by the glycoprotein (GP) IIb/IIIa receptor complex, triggered the development of agents capable of interfering with this platelet receptor complex. Several large clinical trials have demonstrated the effectiveness of this class of agents. The first of these agents to show beneficial effects after coronary interventions was the mouse/human chimeric Fab fragment antibody c7E3 (abciximab; ReoPro). This study analyzes whether the addition of heparin to the GP IIb/IIIa antagonist abciximab would enhance the antithrombotic effect. Blood drawn directly from patients on aspirin who underwent interventional procedures perfused an ex vivo perfusion chamber containing a severely injured arterial wall at local rheologic conditions of a mildly stenosed coronary artery. Blood was perfused directly from patients at baseline and following administration of heparin, abciximab, or both. The antithrombotic effects of the 3 treatments were assessed by reduction of the thrombus formation on the perfused specimens. Thrombus formation at baseline was not significantly modified by the administration of heparin (13,897 ± 1,316 vs 11,917 ± 1,519 μm2). Abciximab produced a 58% reduction in thrombus formation (11,631 ± 861 vs 4,925 ± 585 μm2; p <0.001). The addition of heparin to abciximab did not further reduce thrombus area versus abciximab alone (5,651 ± 581 vs 4,925 ± 585 μm2). Thus, our data show that abciximab dramatically decreases mural thrombus formation and that combining heparin with abciximab did not add any additional antithrombotic effect to abciximab alone. Copyright (C) 2000 Excerpta Medica Inc.

Original languageEnglish
Pages (from-to)1167-1172
Number of pages6
JournalAmerican Journal of Cardiology
Volume85
Issue number10
DOIs
StatePublished - 15 May 2000
Externally publishedYes

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