Antiplatelet therapy for coronary artery disease in 2023: current status and future prospects

Rishi Chandiramani, Alessandro Spirito, James W. Johnson, Adhya Mehta, Birgit Vogel, Robert T. Faillace, Roxana Mehran

Research output: Contribution to journalReview articlepeer-review


Introduction: Antiplatelet therapy is the cornerstone for prevention and management of ischemic complications among patients with coronary artery disease. Over the past decades, advancement in stent technologies and increasing awareness about the prognostic impact of major bleeding have led to evolving priorities in the management of antithrombotic regimens, from exclusive concerns regarding recurrent ischemic events to an individualized equipoise between ischemic and bleeding risk through a patient-centered comprehensive approach. Areas covered: The purpose of this review is to highlight the current evidence that supports the various management strategies for antiplatelet therapy and discuss future directions of pharmacological regimens for coronary syndromes. We will also discuss the rationale behind use of antiplatelet therapy, current guideline recommendations, risk scores for ischemic and bleeding risk evaluation, and tools to help assess treatment response. Expert opinion: While tremendous advancements have been made in antithrombotic agents and regimens, future directions for antiplatelet therapy in patients with coronary artery disease would involve focus on novel therapeutic targets, development of new antiplatelet agents, implementation of more innovative regimens with current agents and further research to validate contemporary antiplatelet strategies.

Original languageEnglish
Pages (from-to)311-328
Number of pages18
JournalExpert Review of Cardiovascular Therapy
Issue number5
StatePublished - 2023


  • Antiplatelet therapy
  • P2Y inhibitor
  • aspirin
  • bleeding
  • dual antiplatelet therapy
  • oral anticoagulation
  • pharmacology
  • thrombosis


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