TY - CHAP
T1 - Antiplatelet Therapies in Unstable Angina and Non-ST Segment Elevation Myocardial Infarction
AU - Anwaruddin, Saif
AU - Bhatt, Deepak L.
N1 - Publisher Copyright:
© Humana Press, a part of Springer Science+Business Media, LLC 2010.
PY - 2010
Y1 - 2010
N2 - The central role of the platelet in the pathophysiology of acute coronary syndromes (ACS) has been well established. The significant morbidity and mortality associated with ACS has fostered great interest and effort in identifying various antiplatelet and antithrombotic regimens as well as developing novel agents in order to abrogate the platelet and its associated prothrombotic effects. Aspirin remains the integral component of all therapeutic strategies for ACS. When used in combination with thienopyridines (i.e., clopidogrel), GP IIb/IIIa inhibitors (abciximab, eptifibatide, tirofiban), or both, patients have experienced improved outcomes in this setting. However, with more potent antiplatelet regimens comes an increased risk of bleeding. Thus, the search for more potent antiplatelet agents with a decreased risk of bleeding continues for this patient population.
AB - The central role of the platelet in the pathophysiology of acute coronary syndromes (ACS) has been well established. The significant morbidity and mortality associated with ACS has fostered great interest and effort in identifying various antiplatelet and antithrombotic regimens as well as developing novel agents in order to abrogate the platelet and its associated prothrombotic effects. Aspirin remains the integral component of all therapeutic strategies for ACS. When used in combination with thienopyridines (i.e., clopidogrel), GP IIb/IIIa inhibitors (abciximab, eptifibatide, tirofiban), or both, patients have experienced improved outcomes in this setting. However, with more potent antiplatelet regimens comes an increased risk of bleeding. Thus, the search for more potent antiplatelet agents with a decreased risk of bleeding continues for this patient population.
KW - Acute coronary syndromes
KW - Aspirin
KW - Clopidogrel
KW - Glycoprotein IIb/IIIa inhibitors
KW - Non-T-segment-elevation myocardial infarction
KW - Percutaneous coronary intervention
KW - ST segment-elevation myocardial infarction
KW - Thienopyridines
UR - https://www.scopus.com/pages/publications/105036644788
U2 - 10.1007/978-1-60327-235-3_7
DO - 10.1007/978-1-60327-235-3_7
M3 - Chapter
AN - SCOPUS:105036644788
T3 - Contemporary Cardiology
SP - 145
EP - 163
BT - Contemporary Cardiology
PB - Springer International Publishing
ER -