Antioxidant activity of oligosaccharide ester extracted from Polygala tenuifolia roots in senescence-accelerated mice

Ping Liu, Yuan Hu, Dai Hong Guo, Bao Rong Lu, Khalid Rahman, Li Hua Mu, Dong Xiao Wang

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

The constituents of the ethanol extract from the root of Polygala tenuifolia Willd. (Polygalaceae) were investigated for antioxidant activity in senescence-accelerated mice. Consequently, two relevant samples were obtained, a fraction separated by macroporous resin (YZ-OE), and a major pure crystal of 3,6′-disinapoyl sucrose (DISS). Based on HPLC-ESI-MS analysis, the most constituents in the YZ-OE fraction from the extract of P. tenuifolia were oligosaccharide esters. The antioxidant activities of these two samples were evaluated using the accelerated senescence-prone, short-lived mice (SAMP) in vivo. The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) were increased significantly in SAMP mice fed oligosaccharide esters (YZ-OE 50mg/kg) and its constituents (DISS 50mg/kg). However, the content of malondialdehyde (MDA) was increased in the blood and liver of SAMP mice. But when given YZ-OE, it could be decreased, by 44.3% and 47.5%, respectively, compared with the SAMP model. Results from the analyses indicated that the oligosaccharide esters (YZ-OE) from roots of P. tenuifolia had a high in vivo antioxidant activity.

Original languageEnglish
Pages (from-to)828-833
Number of pages6
JournalPharmaceutical Biology
Volume48
Issue number7
DOIs
StatePublished - Jul 2010
Externally publishedYes

Keywords

  • Accelerated senescence-prone mouse
  • Antioxidant activity
  • Glutathione peroxidase
  • Malondialdehyde
  • Oligosaccharide ester
  • Superoxide dismutase

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