Abstract
Metastasis is an intricate process whereby tumor cells migrate from the primary tumor, survive in the circulation, seed distal organs, and proliferate to create metastatic foci. CD8+ T cells can detect and eliminate tumor cells. Research on CD8+ T cell–dependent antitumor immunity has classically focused on its role in the primary tumor. There is increasing evidence, however, that CD8+ T cells have unique antimetastatic functions in various steps of the metastatic cascade. Here, we review the mechanisms whereby CD8+ T cells control metastatic lesions. We discuss their role in each step of metastasis, metastatic dormancy, and metastatic clonal evolution as well as the consequent clinical repercussions.
Original language | English |
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Pages (from-to) | 145-157 |
Number of pages | 13 |
Journal | Trends in Cancer |
Volume | 8 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2022 |
Keywords
- CD8 T cells
- immunoediting
- metastasis
- metastatic dormancy