Antimetastatic defense by CD8+ T cells

Paulino Tallón de Lara, Héctor Castañón, Michelle Sterpi, Maries van den Broek

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Metastasis is an intricate process whereby tumor cells migrate from the primary tumor, survive in the circulation, seed distal organs, and proliferate to create metastatic foci. CD8+ T cells can detect and eliminate tumor cells. Research on CD8+ T cell–dependent antitumor immunity has classically focused on its role in the primary tumor. There is increasing evidence, however, that CD8+ T cells have unique antimetastatic functions in various steps of the metastatic cascade. Here, we review the mechanisms whereby CD8+ T cells control metastatic lesions. We discuss their role in each step of metastasis, metastatic dormancy, and metastatic clonal evolution as well as the consequent clinical repercussions.

Original languageEnglish
Pages (from-to)145-157
Number of pages13
JournalTrends in Cancer
Volume8
Issue number2
DOIs
StatePublished - Feb 2022

Keywords

  • CD8 T cells
  • immunoediting
  • metastasis
  • metastatic dormancy

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