Antimalarial effects of human immunodeficiency virus protease inhibitors in rhesus macaques

Youjia Li; Li Qin; Nanzheng Peng; Guangjie Liu; Siting Zhao; Zhengxiang He; Xiaoping Chen

doi:10.1128/AAC.00085-11

Antimalarial effects of human immunodeficiency virus protease inhibitors in rhesus macaques

Youjia Li, Li Qin, Nanzheng Peng, Guangjie Liu, Siting Zhao, Zhengxiang He, Xiaoping Chen

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The antimalarial activity of the human immunodeficiency virus protease inhibitors indinavir and saquinavir was evaluated in rhesus macaques for the first time. Indinavir effectively suppressed the growth of Plasmodium cynomolgi and Plasmodium knowlesi in vivo after a 7- or 3-day treatment, respectively, with clinically relevant doses, whereas saquinavir showed only weak activity against P. cynomolgi.

Original language	English
Pages (from-to)	3039-3042
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	55
Issue number	6
DOIs	https://doi.org/10.1128/AAC.00085-11
State	Published - Jun 2011
Externally published	Yes

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title = "Antimalarial effects of human immunodeficiency virus protease inhibitors in rhesus macaques",

abstract = "The antimalarial activity of the human immunodeficiency virus protease inhibitors indinavir and saquinavir was evaluated in rhesus macaques for the first time. Indinavir effectively suppressed the growth of Plasmodium cynomolgi and Plasmodium knowlesi in vivo after a 7- or 3-day treatment, respectively, with clinically relevant doses, whereas saquinavir showed only weak activity against P. cynomolgi.",

author = "Youjia Li and Li Qin and Nanzheng Peng and Guangjie Liu and Siting Zhao and Zhengxiang He and Xiaoping Chen",

year = "2011",

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AU - Li, Youjia

AU - Qin, Li

AU - Peng, Nanzheng

AU - Liu, Guangjie

AU - Zhao, Siting

AU - He, Zhengxiang

AU - Chen, Xiaoping

PY - 2011/6

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AB - The antimalarial activity of the human immunodeficiency virus protease inhibitors indinavir and saquinavir was evaluated in rhesus macaques for the first time. Indinavir effectively suppressed the growth of Plasmodium cynomolgi and Plasmodium knowlesi in vivo after a 7- or 3-day treatment, respectively, with clinically relevant doses, whereas saquinavir showed only weak activity against P. cynomolgi.

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M3 - Article

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AN - SCOPUS:79956331996

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 6

ER -

Antimalarial effects of human immunodeficiency virus protease inhibitors in rhesus macaques

Abstract

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