Antigenic variants of influenza viruses: Marked differences in the frequencies of variants selected with different monoclonal antibodies

Michael D. Lubeck, Jerome L. Schulman, Peter Palese

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Monoclonal antibodies against the hemagglutinin of two influenza A viruses and one influenza B virus were used to analyze the frequencies of antigenic variant subpopulations in cloned virus seeds. Antigenic variants selected with monoclonal antibodies specific for different antigenic determinants were obtained over a wide range of frequencies. With one monoclonal antibody directed to the hemagglutinin of A/PR/8/34 virus antigenic variants were isolated at a frequency of 10-4.4, whereas another monoclonal antibody, specific for the hemagglutinin of X-31 virus, completely neutralized all infectious virus in the X-31 virus seeds examined, indicating a frequency of antigenic variation, for one seed at least, of less than 10-8.1.

Original languageEnglish
Pages (from-to)458-462
Number of pages5
JournalVirology
Volume102
Issue number2
DOIs
StatePublished - 30 Apr 1980
Externally publishedYes

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