TY - JOUR
T1 - Antigenic characterization of a new gibbon ape leukemia virus isolate
T2 - Seroepidemiologic assessment of an outbreak of gibbon leukemia
AU - Krakower, Jeffery M.
AU - Tronick, Steven R.
AU - Gallagher, Robert E.
AU - Gallo, Robert C.
AU - Aaronson, Stuart A.
PY - 1978/12/15
Y1 - 1978/12/15
N2 - A type‐C virus recently isolated from a leukemic gibbon in a colony located on Hall's Island, Bermuda, was characterized with respect to the antigenic properties of its gag and env gene‐coded proteins. This virus, designated GaLV‐H, was found to be closely related immunologically to type‐C viruses previously isolated from gibbons (GaLV‐SF, GaLV‐SEATO, GaLV‐Br) and from woolly monkey (SSAV). However, GaLV‐H was readily differentiated from these isolates in a radioimmunoassay for its env gene product, gp70. Seroepidemiology established that GaLV‐H was horizontally transmitted among gibbons within the colony. There was no evidence of exposure leading to an immune response to the virus or viral antigenemia in humans working in association with these animals.
AB - A type‐C virus recently isolated from a leukemic gibbon in a colony located on Hall's Island, Bermuda, was characterized with respect to the antigenic properties of its gag and env gene‐coded proteins. This virus, designated GaLV‐H, was found to be closely related immunologically to type‐C viruses previously isolated from gibbons (GaLV‐SF, GaLV‐SEATO, GaLV‐Br) and from woolly monkey (SSAV). However, GaLV‐H was readily differentiated from these isolates in a radioimmunoassay for its env gene product, gp70. Seroepidemiology established that GaLV‐H was horizontally transmitted among gibbons within the colony. There was no evidence of exposure leading to an immune response to the virus or viral antigenemia in humans working in association with these animals.
UR - http://www.scopus.com/inward/record.url?scp=0018146050&partnerID=8YFLogxK
U2 - 10.1002/ijc.2910220613
DO - 10.1002/ijc.2910220613
M3 - Article
C2 - 82546
AN - SCOPUS:0018146050
SN - 0020-7136
VL - 22
SP - 715
EP - 720
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 6
ER -