Antigen processing for MHC class II presentation via autophagy

Christian Münz

Research output: Contribution to journalReview articlepeer-review

86 Scopus citations

Abstract

T cells recognize proteolytic fragments of antigens that are presented to them on major histocompatibility complex (MHC) molecules. MHC class I molecules present primarily products of proteasomal proteolysis to CD8+ T cells, while MHC class II molecules display mainly degradation products of lysosomes for stimulation of CD4+T cells. Macroautophagy delivers intracellular proteins to lysosomal degradation, and contributes in this fashion to the pool of MHC class II displayed peptides. Both selfand pathogen-derived MHC class II ligands are generated by this pathway. In addition, however, recent evidence points also to regulation of extracellular antigen processing by macroautophagy. In this review, I will discuss these two aspects of antigen processing for MHC class II presentation via macroautophagy, namely its influence on intracellular and extracellular antigen presentation to CD4+ T cells.

Original languageEnglish
Article numberArticle 9
JournalFrontiers in Immunology
Volume3
Issue numberFEB
DOIs
StatePublished - 2012
Externally publishedYes

Keywords

  • Amphisome
  • Autophagosome
  • CD4 T cell
  • Lysosome
  • MHC class II containing compartment

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