Antifungal activity of antimicrobial-impregnated devices

R. O. Darouiche; M. D. Mansouri; E. M. Kojic

doi:10.1111/j.1469-0691.2006.01369.x

Antifungal activity of antimicrobial-impregnated devices

R. O. Darouiche, M. D. Mansouri, E. M. Kojic

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The in-vitro and in-vivo efficacy against Candida albicans and Candida krusei of devices impregnated with chlorhexidine and chloroxylenol was examined. The impregnated devices produced large zones of inhibition against both organisms (mean size, 39 mm and 38 mm, respectively). In a rabbit model in which segments of silicone catheters were placed percutaneously, non-impregnated devices were twice as likely as impregnated devices to become colonised with either C. albicans or C. krusei. Impregnated devices also had significantly lower colony counts of C. albicans (58 vs. 1361 CFU; p 0.008) and C. krusei (19 vs. 764 CFU; p 0.008.

Original language	English
Pages (from-to)	397-399
Number of pages	3
Journal	Clinical Microbiology and Infection
Volume	12
Issue number	4
DOIs	https://doi.org/10.1111/j.1469-0691.2006.01369.x
State	Published - Apr 2006
Externally published	Yes

Keywords

Candida albicans
Candida krusei
Chlorhexidine
Chloroxylenol
Impregnated devices
Rabbit model

Access to Document

10.1111/j.1469-0691.2006.01369.x

Cite this

@article{55cbd9e4e6d84e87b7a745fac1390fab,

title = "Antifungal activity of antimicrobial-impregnated devices",

abstract = "The in-vitro and in-vivo efficacy against Candida albicans and Candida krusei of devices impregnated with chlorhexidine and chloroxylenol was examined. The impregnated devices produced large zones of inhibition against both organisms (mean size, 39 mm and 38 mm, respectively). In a rabbit model in which segments of silicone catheters were placed percutaneously, non-impregnated devices were twice as likely as impregnated devices to become colonised with either C. albicans or C. krusei. Impregnated devices also had significantly lower colony counts of C. albicans (58 vs. 1361 CFU; p 0.008) and C. krusei (19 vs. 764 CFU; p 0.008.",

keywords = "Candida albicans, Candida krusei, Chlorhexidine, Chloroxylenol, Impregnated devices, Rabbit model",

author = "Darouiche, {R. O.} and Mansouri, {M. D.} and Kojic, {E. M.}",

note = "Funding Information: This study was supported by funds from Baylor College of Medicine, Houston, TX, USA. Baylor College of Medicine owns the rights to a patent that describes the use of the combination of chlorhexidine and chloroxylenol for impregnation of medical devices, but neither Baylor College of Medicine nor the authors of this study are engaged in any commercial or consulting agreements that are related to this combination of agents.",

year = "2006",

month = apr,

doi = "10.1111/j.1469-0691.2006.01369.x",

language = "English",

volume = "12",

pages = "397--399",

journal = "Clinical Microbiology and Infection",

issn = "1198-743X",

publisher = "Elsevier Ltd.",

number = "4",

}

TY - JOUR

T1 - Antifungal activity of antimicrobial-impregnated devices

AU - Darouiche, R. O.

AU - Mansouri, M. D.

AU - Kojic, E. M.

N1 - Funding Information: This study was supported by funds from Baylor College of Medicine, Houston, TX, USA. Baylor College of Medicine owns the rights to a patent that describes the use of the combination of chlorhexidine and chloroxylenol for impregnation of medical devices, but neither Baylor College of Medicine nor the authors of this study are engaged in any commercial or consulting agreements that are related to this combination of agents.

PY - 2006/4

Y1 - 2006/4

N2 - The in-vitro and in-vivo efficacy against Candida albicans and Candida krusei of devices impregnated with chlorhexidine and chloroxylenol was examined. The impregnated devices produced large zones of inhibition against both organisms (mean size, 39 mm and 38 mm, respectively). In a rabbit model in which segments of silicone catheters were placed percutaneously, non-impregnated devices were twice as likely as impregnated devices to become colonised with either C. albicans or C. krusei. Impregnated devices also had significantly lower colony counts of C. albicans (58 vs. 1361 CFU; p 0.008) and C. krusei (19 vs. 764 CFU; p 0.008.

AB - The in-vitro and in-vivo efficacy against Candida albicans and Candida krusei of devices impregnated with chlorhexidine and chloroxylenol was examined. The impregnated devices produced large zones of inhibition against both organisms (mean size, 39 mm and 38 mm, respectively). In a rabbit model in which segments of silicone catheters were placed percutaneously, non-impregnated devices were twice as likely as impregnated devices to become colonised with either C. albicans or C. krusei. Impregnated devices also had significantly lower colony counts of C. albicans (58 vs. 1361 CFU; p 0.008) and C. krusei (19 vs. 764 CFU; p 0.008.

KW - Candida albicans

KW - Candida krusei

KW - Chlorhexidine

KW - Chloroxylenol

KW - Impregnated devices

KW - Rabbit model

UR - http://www.scopus.com/inward/record.url?scp=33644758269&partnerID=8YFLogxK

U2 - 10.1111/j.1469-0691.2006.01369.x

DO - 10.1111/j.1469-0691.2006.01369.x

M3 - Article

C2 - 16524420

AN - SCOPUS:33644758269

SN - 1198-743X

VL - 12

SP - 397

EP - 399

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

IS - 4

ER -

Antifungal activity of antimicrobial-impregnated devices

Abstract

Keywords

Access to Document

Fingerprint

Cite this