Antifungal activity of antimicrobial-impregnated devices

R. O. Darouiche, M. D. Mansouri, E. M. Kojic

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The in-vitro and in-vivo efficacy against Candida albicans and Candida krusei of devices impregnated with chlorhexidine and chloroxylenol was examined. The impregnated devices produced large zones of inhibition against both organisms (mean size, 39 mm and 38 mm, respectively). In a rabbit model in which segments of silicone catheters were placed percutaneously, non-impregnated devices were twice as likely as impregnated devices to become colonised with either C. albicans or C. krusei. Impregnated devices also had significantly lower colony counts of C. albicans (58 vs. 1361 CFU; p 0.008) and C. krusei (19 vs. 764 CFU; p 0.008.

Original languageEnglish
Pages (from-to)397-399
Number of pages3
JournalClinical Microbiology and Infection
Issue number4
StatePublished - Apr 2006
Externally publishedYes


  • Candida albicans
  • Candida krusei
  • Chlorhexidine
  • Chloroxylenol
  • Impregnated devices
  • Rabbit model


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