Antidepressants, mood-stabilizing drugs, and mitochondrial functions: For better or for worse

Graeme Preston; Dana El Soufi El Sabbagh; Tim L. Emmerzaal; Eva Morava; Ana Cristina Andreazza; Shamima Rahman; Tamas Kozicz

doi:10.1016/B978-0-323-88462-4.00016-X

Antidepressants, mood-stabilizing drugs, and mitochondrial functions: For better or for worse

Graeme Preston, Dana El Soufi El Sabbagh, Tim L. Emmerzaal, Eva Morava, Ana Cristina Andreazza, Shamima Rahman, Tamas Kozicz

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Psychiatric manifestations of primary mitochondrial diseases are increasingly recognized, and optimal strategies for managing these represent a significant unmet clinical need for this group of patients with complex multisystem symptomatology and high mortality and morbidity. Secondary mitochondrial dysfunction and oxidative stress have also been implicated in the pathophysiology of various psychiatric diseases. It has been well documented that medications used to treat neuropsychiatric disorders could directly modulate mitochondrial functions. The objective of this book chapter is to review antidepressant drugs and other psychiatric medications that are available for the treatment of psychiatric disorders and the evidence that exists in relation to the mitochondria using these drugs.

Original language	English
Title of host publication	Mitochondrial Intoxication
Publisher	Elsevier
Pages	323-349
Number of pages	27
ISBN (Electronic)	9780323884624
DOIs	https://doi.org/10.1016/B978-0-323-88462-4.00016-X
State	Published - 1 Jan 2022
Externally published	Yes

Keywords

Antidepressants
Bioenergetics
Mitochondria
Mitochondrial dysfunction
Oxidative phosphorylation
Oxidative stress
Primary mitochondrial disorders
Psychiatric medications
Secondary mitochondrial dysfunction

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10.1016/B978-0-323-88462-4.00016-X

Cite this

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abstract = "Psychiatric manifestations of primary mitochondrial diseases are increasingly recognized, and optimal strategies for managing these represent a significant unmet clinical need for this group of patients with complex multisystem symptomatology and high mortality and morbidity. Secondary mitochondrial dysfunction and oxidative stress have also been implicated in the pathophysiology of various psychiatric diseases. It has been well documented that medications used to treat neuropsychiatric disorders could directly modulate mitochondrial functions. The objective of this book chapter is to review antidepressant drugs and other psychiatric medications that are available for the treatment of psychiatric disorders and the evidence that exists in relation to the mitochondria using these drugs.",

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AU - Preston, Graeme

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AU - Andreazza, Ana Cristina

AU - Rahman, Shamima

AU - Kozicz, Tamas

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KW - Bioenergetics

KW - Mitochondria

KW - Mitochondrial dysfunction

KW - Oxidative phosphorylation

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BT - Mitochondrial Intoxication

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Antidepressants, mood-stabilizing drugs, and mitochondrial functions: For better or for worse

Abstract

Keywords

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