Antidepressant-like effects of piperine and its neuroprotective mechinism

Hongbo Liao, Ping Liu, Yuan Hu, Dongxiao Wang, Hui Lin

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Objective: To observe the antidepressant effect of pipeline and its neuroprotective mechinism. Method: The behavioral studies were performed in forced swimming test (FST) and tail suspension test (TST). To further explore the mechanisms underlying their antidepressant-like activities, CORT-induced neuroblastoma SH-SY5Y cells and isolated and cultured neural progenitor cells. By using MTT assay, the effect of pipeline on neural cells proliferation was observed. Result: The research results indicated that after a week of administration, pipeline (10, 20 mg·kg-1) could significantly reduce the duration of immobility in both FST and TST. Piperine has the protective effect on neuroblastoma cells and increased proliferation of hippocampus neural progenitor cells. Conclusion: In the present study, we demonstrated that the antidepressant-like effects of piperine and its mechanisms might be involved by up-regulation of the progenitor cell proliferation of hippocampus and cytoprotective activity.

Original languageEnglish
Pages (from-to)1562-1565
Number of pages4
JournalZhongguo Zhongyao Zazhi
Issue number12
StatePublished - Jun 2009
Externally publishedYes


  • Antidepressant
  • Neural progenitor cells
  • Piperine
  • SH-SY5Y


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