Anticholinergic behavioral effect of phencyclidine

Stanley D. Glick; Russell D. Cox; Saul Maayani; Richard C. Meibach

doi:10.1016/0014-2999(79)90029-3

Anticholinergic behavioral effect of phencyclidine

Stanley D. Glick
, Russell D. Cox
, Saul Maayani
, Richard C. Meibach

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Phencyclidine (PCP) impaired spatial alternation performance in rats. This effect was mimicked by antimuscarinic anticholinergics (scopolamine, atropine) and PCP derivatives (ketamine, cyclohexamine) but not by a variety of other agents. Muscarinic cholinergic agonists antagonized PCP. Impairment of spatial alteration performance by PCP appears to be mediated, at least in part, by an anticholinergic action; this is the first instance of a behavioral effect of PCP that can be largely attributed to a specific mechanism.

Original language	English
Pages (from-to)	103-106
Number of pages	4
Journal	European Journal of Pharmacology
Volume	59
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-2999(79)90029-3
State	Published - 26 Oct 1979
Externally published	Yes

Keywords

Anticholinergic
Behavior
Phencyclidine
Spatial alternation

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10.1016/0014-2999(79)90029-3

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@article{b0f9c33a6d2e41aeb4f471d7831c96cf,

title = "Anticholinergic behavioral effect of phencyclidine",

abstract = "Phencyclidine (PCP) impaired spatial alternation performance in rats. This effect was mimicked by antimuscarinic anticholinergics (scopolamine, atropine) and PCP derivatives (ketamine, cyclohexamine) but not by a variety of other agents. Muscarinic cholinergic agonists antagonized PCP. Impairment of spatial alteration performance by PCP appears to be mediated, at least in part, by an anticholinergic action; this is the first instance of a behavioral effect of PCP that can be largely attributed to a specific mechanism.",

keywords = "Anticholinergic, Behavior, Phencyclidine, Spatial alternation",

author = "Glick, \{Stanley D.\} and Cox, \{Russell D.\} and Saul Maayani and Meibach, \{Richard C.\}",

note = "Funding Information: * Supported by NIDA Research Scientist Development Award DA 70082.",

year = "1979",

month = oct,

day = "26",

doi = "10.1016/0014-2999(79)90029-3",

language = "English",

volume = "59",

pages = "103--106",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Anticholinergic behavioral effect of phencyclidine

AU - Glick, Stanley D.

AU - Cox, Russell D.

AU - Maayani, Saul

AU - Meibach, Richard C.

N1 - Funding Information: * Supported by NIDA Research Scientist Development Award DA 70082.

PY - 1979/10/26

Y1 - 1979/10/26

N2 - Phencyclidine (PCP) impaired spatial alternation performance in rats. This effect was mimicked by antimuscarinic anticholinergics (scopolamine, atropine) and PCP derivatives (ketamine, cyclohexamine) but not by a variety of other agents. Muscarinic cholinergic agonists antagonized PCP. Impairment of spatial alteration performance by PCP appears to be mediated, at least in part, by an anticholinergic action; this is the first instance of a behavioral effect of PCP that can be largely attributed to a specific mechanism.

AB - Phencyclidine (PCP) impaired spatial alternation performance in rats. This effect was mimicked by antimuscarinic anticholinergics (scopolamine, atropine) and PCP derivatives (ketamine, cyclohexamine) but not by a variety of other agents. Muscarinic cholinergic agonists antagonized PCP. Impairment of spatial alteration performance by PCP appears to be mediated, at least in part, by an anticholinergic action; this is the first instance of a behavioral effect of PCP that can be largely attributed to a specific mechanism.

KW - Anticholinergic

KW - Behavior

KW - Phencyclidine

KW - Spatial alternation

UR - https://www.scopus.com/pages/publications/0018673681

U2 - 10.1016/0014-2999(79)90029-3

DO - 10.1016/0014-2999(79)90029-3

M3 - Article

C2 - 510389

AN - SCOPUS:0018673681

SN - 0014-2999

VL - 59

SP - 103

EP - 106

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1-2

ER -

Anticholinergic behavioral effect of phencyclidine

Abstract

Keywords

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