TY - JOUR
T1 - Antibody to a mutagenic peptide of herpes simplex virus in young adult patients with cancer of the head and neck
AU - Das, Chandra M.
AU - Schantz, Stimson P.
AU - Shillitoe, Edward J.
N1 - Funding Information:
Supported h> PHS grant DEO7007. C .I) I\ wpported b> I’HS grant DE05577. The synthetic peptide wa\ made in the Synthetic Antigen Laboratory. M.D. Anderson Cancer Center, Hhich is supported by PHS grant CA.16672. “Postdoctoral Fellou. Department 01’ Microbiology, l‘exas t1ealth Science Center Dental Branch. “Associate Prof’essor of Surger), Department ol’ tlend and Neck Surgery. Memorial Sloan-Kettering C‘ancer Ccnru ‘Professor and Chairman, Drpartment of Microbiology. of Texas I lealth Science Center Dental Branch. cop)~rigllt 1993 lq Moshq-Year Book, Inc OO30-4220/93 /$ I .OO + IO 7/ 14/45313
PY - 1993/5
Y1 - 1993/5
N2 - Cancer of the head and neck has been associated with herpes simplex virus type-1 by serologic studies that have used virus particles or complex mixtures of viral proteins as antigens. Recently a peptide was found to be encoded by the transforming region of the virus that is mutagenic and is postulated to be involved in cell transformation. Sera from young adult patients with head and neck cancer and from control subjects were examined for the presence of antibody to this peptide with the use of an enzyme-linked immunosorbent assay. Antibody to the peptide was detected in many sera and showed a significant correlation with antibody to the virus in sera from control subjects. Antipeptide antibodies were largely of the IgM isotype, and patients had significantly higher levels of antibody than control subjects. This study is consistent with an association between HSV-1 and head and neck cancer and suggests that this viral peptide should be investigated further for its role in carcinogenesis.
AB - Cancer of the head and neck has been associated with herpes simplex virus type-1 by serologic studies that have used virus particles or complex mixtures of viral proteins as antigens. Recently a peptide was found to be encoded by the transforming region of the virus that is mutagenic and is postulated to be involved in cell transformation. Sera from young adult patients with head and neck cancer and from control subjects were examined for the presence of antibody to this peptide with the use of an enzyme-linked immunosorbent assay. Antibody to the peptide was detected in many sera and showed a significant correlation with antibody to the virus in sera from control subjects. Antipeptide antibodies were largely of the IgM isotype, and patients had significantly higher levels of antibody than control subjects. This study is consistent with an association between HSV-1 and head and neck cancer and suggests that this viral peptide should be investigated further for its role in carcinogenesis.
UR - https://www.scopus.com/pages/publications/0027213103
U2 - 10.1016/0030-4220(93)90235-V
DO - 10.1016/0030-4220(93)90235-V
M3 - Article
C2 - 8387664
AN - SCOPUS:0027213103
SN - 0030-4220
VL - 75
SP - 610
EP - 614
JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
IS - 5
ER -