Antibody-mediated regulation of basophils: emerging views and clinical implications

Kang Chen, Yujing Hao, Mauricio Guzmán, Genxia Li, Andrea Cerutti

    Research output: Contribution to journalReview articlepeer-review

    1 Scopus citations

    Abstract

    An increasing number of human diseases, including allergies, infections, inflammation, and cancer, involve roles for basophils. Traditionally viewed as the rarest leukocytes that are present only in the circulation, basophils have recently emerged as important players in systemic as well as tissue-specific immune responses. Their functions are regulated by immunoglobulins (Igs), and this enables basophils to integrate diverse adaptive and innate immunity signals. IgE is well known to regulate basophil responses in the context of type 2 immunity and allergic inflammation; however, growing evidence shows that IgG, IgA, and IgD also shape specific aspects of basophil functions relevant to many human diseases. We discuss recent mechanistic advances underpinning antibody-mediated basophil responses and propose strategies for the treatment of basophil-associated disorders.

    Original languageEnglish
    Pages (from-to)408-423
    Number of pages16
    JournalTrends in Immunology
    Volume44
    Issue number6
    DOIs
    StatePublished - Jun 2023

    Keywords

    • IgA
    • IgD
    • IgE
    • IgG
    • allergy
    • antibody
    • basophil
    • immunotherapy

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