Antibodies to Retroviral Proteins and Reverse Transcriptase Activity in Patients With Essential Cryoglobulinemia

Andras Perl; Peter D. Gorevic; John J. Condemi; Lawrence Papsidero; Bernard J. Poiesz; George N. Abraham

doi:10.1002/art.1780341017

Antibodies to Retroviral Proteins and Reverse Transcriptase Activity in Patients With Essential Cryoglobulinemia

Andras Perl
, Peter D. Gorevic
, John J. Condemi
, Lawrence Papsidero
, Bernard J. Poiesz
, George N. Abraham

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Human T cell lymphotropic virus type I (HTLV‐I) gag and env protein–specific antibodies were identified in 6 of 13 patients with essential cryoglobulinemia (EC), by Western blot and radioimmunoprecipitation analysis. Supernatants of cells from 2 of the 5 EC patients tested showed reverse transcriptase activity. DNA sequences homologous to HTLV‐I could not be detected by polymerase chain reaction, thus excluding the presence of prototype HTLV‐I in each patient with EC. The data suggest that retroviral proteins distinct from but related to HTLV‐I may be involved in the pathogenesis of EC in some patients.

Original language	English
Pages (from-to)	1313-1318
Number of pages	6
Journal	Arthritis and Rheumatology
Volume	34
Issue number	10
DOIs	https://doi.org/10.1002/art.1780341017
State	Published - 10 Oct 1991
Externally published	Yes

Access to Document

10.1002/art.1780341017

Cite this

@article{c5def41e98924b8380d42efcaa283853,

title = "Antibodies to Retroviral Proteins and Reverse Transcriptase Activity in Patients With Essential Cryoglobulinemia",

abstract = "Human T cell lymphotropic virus type I (HTLV‐I) gag and env protein–specific antibodies were identified in 6 of 13 patients with essential cryoglobulinemia (EC), by Western blot and radioimmunoprecipitation analysis. Supernatants of cells from 2 of the 5 EC patients tested showed reverse transcriptase activity. DNA sequences homologous to HTLV‐I could not be detected by polymerase chain reaction, thus excluding the presence of prototype HTLV‐I in each patient with EC. The data suggest that retroviral proteins distinct from but related to HTLV‐I may be involved in the pathogenesis of EC in some patients.",

author = "Andras Perl and Gorevic, \{Peter D.\} and Condemi, \{John J.\} and Lawrence Papsidero and Poiesz, \{Bernard J.\} and Abraham, \{George N.\}",

year = "1991",

month = oct,

day = "10",

doi = "10.1002/art.1780341017",

language = "English",

volume = "34",

pages = "1313--1318",

journal = "Arthritis and Rheumatology",

issn = "0004-3591",

publisher = "John Wiley and Sons Ltd",

number = "10",

}

TY - JOUR

T1 - Antibodies to Retroviral Proteins and Reverse Transcriptase Activity in Patients With Essential Cryoglobulinemia

AU - Perl, Andras

AU - Gorevic, Peter D.

AU - Condemi, John J.

AU - Papsidero, Lawrence

AU - Poiesz, Bernard J.

AU - Abraham, George N.

PY - 1991/10/10

Y1 - 1991/10/10

N2 - Human T cell lymphotropic virus type I (HTLV‐I) gag and env protein–specific antibodies were identified in 6 of 13 patients with essential cryoglobulinemia (EC), by Western blot and radioimmunoprecipitation analysis. Supernatants of cells from 2 of the 5 EC patients tested showed reverse transcriptase activity. DNA sequences homologous to HTLV‐I could not be detected by polymerase chain reaction, thus excluding the presence of prototype HTLV‐I in each patient with EC. The data suggest that retroviral proteins distinct from but related to HTLV‐I may be involved in the pathogenesis of EC in some patients.

AB - Human T cell lymphotropic virus type I (HTLV‐I) gag and env protein–specific antibodies were identified in 6 of 13 patients with essential cryoglobulinemia (EC), by Western blot and radioimmunoprecipitation analysis. Supernatants of cells from 2 of the 5 EC patients tested showed reverse transcriptase activity. DNA sequences homologous to HTLV‐I could not be detected by polymerase chain reaction, thus excluding the presence of prototype HTLV‐I in each patient with EC. The data suggest that retroviral proteins distinct from but related to HTLV‐I may be involved in the pathogenesis of EC in some patients.

UR - https://www.scopus.com/pages/publications/0026048364

U2 - 10.1002/art.1780341017

DO - 10.1002/art.1780341017

M3 - Article

C2 - 1718286

AN - SCOPUS:0026048364

SN - 0004-3591

VL - 34

SP - 1313

EP - 1318

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

IS - 10

ER -

Antibodies to Retroviral Proteins and Reverse Transcriptase Activity in Patients With Essential Cryoglobulinemia

Abstract

Access to Document

Fingerprint

Cite this