Antibodies to native tRNA in NZB/NZW mice

Dan Eilat, Alan N. Schechter, Alfred D. Steinberg

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

ANTIBODIES to native DNA, double-stranded RNA, and various synthetic polyribonucleotides occur with great frequency in patients with systemic lupus erythematosus (SLE)1. These antibodies are also present in the New Zealand mouse, particularly the NZB/NZW F1 hybrid, which is considered a good animal model for human SLE2. We report here the presence and characterisation of antibodies that bind tRNA, specifically in its native conformation, in sera from old NZB/NZW mice.

Original languageEnglish
Pages (from-to)141-143
Number of pages3
JournalNature
Volume259
Issue number5539
DOIs
StatePublished - 1976
Externally publishedYes

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