Antibodies to Epstein Barr virus associated antigens in Burkitt's lymphoma

P. Gunven, G. Klein, G. Henle

Research output: Contribution to journalArticlepeer-review


Three antigen systems associated with the Epstein Barr virus were studied by immunofluorescence: membrane antigens (MA), intracellular 'early antigens' (EA), and intracellular viral capsid antigens (VCA). All Burkitt's lymphoma patients studied had antibodies to VCA and MA, and a majority also to EA. The patients had higher titers than control groups. High anti EA titers in patients brought into remissions indicate a bad prognosis as to recurrences. A decrease in antibodies to MA has been seen before late tumor recurrences. BCG inoculations temporarily increased the anti MA titers.

Original languageEnglish
Pages (from-to)813-817
Number of pages5
JournalBibliotheca Haematologica
VolumeVol 39
StatePublished - 1973
Externally publishedYes


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