Antibodies targeting the envelope of HIV-1

Luzia M. Mayr; Susan Zolla-Pazner

doi:10.1128/9781555817411.ch11

Antibodies targeting the envelope of HIV-1

Luzia M. Mayr
, Susan Zolla-Pazner

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

HIV continues to be a major global public health issue, with an estimated 35 million people living with the virus and more than 2 million new infections occurring yearly (1). As part of the natural immune response, antibodies (Abs) exert immune pressure on HIV and play a key role both in controlling the virus and in driving escape mutations in the viral envelope glycoproteins. Therefore, and because the elicitation of Abs is believed to be crucial for an effective vaccine against HIV, Abs targeting HIV have been the focus of intense research in the past years.

Original language	English
Title of host publication	Antibodies for Infectious Diseases
Publisher	wiley
Pages	191-208
Number of pages	18
ISBN (Electronic)	9781683670988
ISBN (Print)	9781555817350
DOIs	https://doi.org/10.1128/9781555817411.ch11
State	Published - 26 May 2015
Externally published	Yes

Keywords

Antibodies target
Antibody response
HIV-1
Immunogen design
Vaccine development
Viral envelope glycoproteins

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10.1128/9781555817411.ch11

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title = "Antibodies targeting the envelope of HIV-1",

abstract = "HIV continues to be a major global public health issue, with an estimated 35 million people living with the virus and more than 2 million new infections occurring yearly (1). As part of the natural immune response, antibodies (Abs) exert immune pressure on HIV and play a key role both in controlling the virus and in driving escape mutations in the viral envelope glycoproteins. Therefore, and because the elicitation of Abs is believed to be crucial for an effective vaccine against HIV, Abs targeting HIV have been the focus of intense research in the past years.",

keywords = "Antibodies target, Antibody response, HIV-1, Immunogen design, Vaccine development, Viral envelope glycoproteins",

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N2 - HIV continues to be a major global public health issue, with an estimated 35 million people living with the virus and more than 2 million new infections occurring yearly (1). As part of the natural immune response, antibodies (Abs) exert immune pressure on HIV and play a key role both in controlling the virus and in driving escape mutations in the viral envelope glycoproteins. Therefore, and because the elicitation of Abs is believed to be crucial for an effective vaccine against HIV, Abs targeting HIV have been the focus of intense research in the past years.

AB - HIV continues to be a major global public health issue, with an estimated 35 million people living with the virus and more than 2 million new infections occurring yearly (1). As part of the natural immune response, antibodies (Abs) exert immune pressure on HIV and play a key role both in controlling the virus and in driving escape mutations in the viral envelope glycoproteins. Therefore, and because the elicitation of Abs is believed to be crucial for an effective vaccine against HIV, Abs targeting HIV have been the focus of intense research in the past years.

KW - Antibodies target

KW - Antibody response

KW - HIV-1

KW - Immunogen design

KW - Vaccine development

KW - Viral envelope glycoproteins

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SN - 9781555817350

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EP - 208

BT - Antibodies for Infectious Diseases

PB - wiley

ER -

Antibodies targeting the envelope of HIV-1

Abstract

Keywords

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