Antibodies in Serum of Patients with Alzheimer's Disease Cause Immunolysis of Cholinergic Nerve Terminals from the Rat Cerebral Cortex

H. F. Bradford; P. Foley; M. Docherty; H. Fillit; V. N. Luine; B. Mcewen; G. Bucht; B. Winbald; J. Hardy

doi:10.1017/S0317167100029875

Antibodies in Serum of Patients with Alzheimer's Disease Cause Immunolysis of Cholinergic Nerve Terminals from the Rat Cerebral Cortex

H. F. Bradford, P. Foley, M. Docherty, H. Fillit, V. N. Luine, B. Mcewen, G. Bucht, B. Winbald, J. Hardy

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Abstract

A blind study showing that serum from patients with Alzheimer's disease causes immunolysis of mammalian brain synaptosomes is reported. Control, aged-matched, sera were largely without effect. The immunolysis was directed mainly against cholinergic synaptosomes. The data support the hypothesis that autoimmune mechanisms may operate in the pathogenesis of Alzheimer's disease.

Original language	English
Pages (from-to)	528-534
Number of pages	7
Journal	Canadian Journal of Neurological Sciences
Volume	16
Issue number	S4
DOIs	https://doi.org/10.1017/S0317167100029875
State	Published - Nov 1989
Externally published	Yes

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title = "Antibodies in Serum of Patients with Alzheimer's Disease Cause Immunolysis of Cholinergic Nerve Terminals from the Rat Cerebral Cortex",

abstract = "A blind study showing that serum from patients with Alzheimer's disease causes immunolysis of mammalian brain synaptosomes is reported. Control, aged-matched, sera were largely without effect. The immunolysis was directed mainly against cholinergic synaptosomes. The data support the hypothesis that autoimmune mechanisms may operate in the pathogenesis of Alzheimer's disease.",

author = "Bradford, \{H. F.\} and P. Foley and M. Docherty and H. Fillit and Luine, \{V. N.\} and B. Mcewen and G. Bucht and B. Winbald and J. Hardy",

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AU - Bradford, H. F.

AU - Foley, P.

AU - Docherty, M.

AU - Fillit, H.

AU - Luine, V. N.

AU - Mcewen, B.

AU - Bucht, G.

AU - Winbald, B.

AU - Hardy, J.

PY - 1989/11

Y1 - 1989/11

N2 - A blind study showing that serum from patients with Alzheimer's disease causes immunolysis of mammalian brain synaptosomes is reported. Control, aged-matched, sera were largely without effect. The immunolysis was directed mainly against cholinergic synaptosomes. The data support the hypothesis that autoimmune mechanisms may operate in the pathogenesis of Alzheimer's disease.

AB - A blind study showing that serum from patients with Alzheimer's disease causes immunolysis of mammalian brain synaptosomes is reported. Control, aged-matched, sera were largely without effect. The immunolysis was directed mainly against cholinergic synaptosomes. The data support the hypothesis that autoimmune mechanisms may operate in the pathogenesis of Alzheimer's disease.

UR - https://www.scopus.com/pages/publications/0024416075

U2 - 10.1017/S0317167100029875

DO - 10.1017/S0317167100029875

M3 - Article

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AN - SCOPUS:0024416075

SN - 0317-1671

VL - 16

SP - 528

EP - 534

JO - Canadian Journal of Neurological Sciences

JF - Canadian Journal of Neurological Sciences

IS - S4

ER -

Antibodies in Serum of Patients with Alzheimer's Disease Cause Immunolysis of Cholinergic Nerve Terminals from the Rat Cerebral Cortex

Abstract

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