@article{3842a32609124f31b9f0cd46c840b729,
title = "Antibodies against lytic and latent Kaposi's sarcoma-associated herpes virus antigens and lymphoma in the European EpiLymph case-control study",
abstract = "Background: Kaposi's sarcoma-associated herpes virus is associated with primary effusion lymphoma and multicentric Castleman's disease.Methods: Seropositivity to lytic and latent Kaposi's sarcoma herpes virus (KSHV) antigens were examined in 2083 lymphomas and 2013 controls from six European countries. Results: Antibodies against KSHV latent and lytic antigens were detectable in 4.5% and 3.4% of controls, respectively, and 3.6% of cases (P0.05). The KSHV seropositivity was associated with splenic marginal zone lymphoma (SMZL) (odds ratio (OR)4.11, 95% confidence interval (CI)1.57-10.83) and multiple myeloma (OR0.31, 95% CI0.11-0.85).Conclusion:The KSHV is unlikely to contribute importantly to lymphomagenesis among immunocompetent subjects. However, the observed association with SMZL may underline a chronic antigen mechanism in its aetiology.",
keywords = "Kaposi's sarcoma-associated herpes virus, epidemiology, human herpes virus 8, lymphoma, serology",
author = "Y. Benavente and G. Mbisa and N. Labo and D. Casabonne and N. Becker and M. Maynadie and L. Foretova and Cocco, {P. L.} and A. Nieters and A. Staines and P. Bofetta and P. Brennan and D. Whitby and {De Sanjos{\'e}}, S.",
note = "Funding Information: Oncologia 2001 (EpiLymph-Italy); Italian Ministry of Education, University and Research (PRIN 2007, 2007WEJLZB); Spanish Ministry of Health grants RCESP (C03/09), RTICESP (C03/10), RTIC (RD06/0020/0095), CIBERESP (06/02/0073), FIS 08-1555 (EpiLymph-Spain) and from the Ag{\`e}ncia de Gesti{\'o} d{\textquoteright}Ajuts Universitaris i de Recerca – Generalitat de Catalunya (AGAUR 2005SGR 00695, AGAUR 2009SGR1465 and AGAUR 2009SGR126) Funding Information: We would like to thank all those who took part in this study, providing questionnaire data and blood samples. This work was supported by a European Commission Grant no. QLK4-CT-2000-00422 (EpiLymph studies); Association pour la Recherche contre le Cancer (ARC no.5111); the Fondation de France (1999 008471; EpiLymphFrance); Compagnia di San Paolo di Torino, Programma",
year = "2011",
month = nov,
day = "22",
doi = "10.1038/bjc.2011.392",
language = "English",
volume = "105",
pages = "1768--1771",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Springer Nature",
number = "11",
}