Abstract
Antibodies against cytomegalovirus-specific early antigens (CMV-EA) were followed in sera, obtained from 15 immunosuppressed renal-allograft recipients. 8 patients (62 sera) showed seroconversion 47-137 days post-transplantation. 5 patients (40 sera) with CMV antibodies at the moment of renal implantation all showed CMV-EA antibody rises. Two patients remained seronegative until 4 years after transplantation. Thus, in immunosuppressed patients, antibodies against CMV-EA remained at high titres during many years (4-8 years) after transplantation as distinct from the apparently transient nature in acutely infected previously healthy adults with CMV mononucleosis or post-perfusion syndrome. These results support the view that CMV-EA antibodies reflect an active viral proliferation in the host.
Original language | English |
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Pages (from-to) | 502-505 |
Number of pages | 4 |
Journal | Clinical and Experimental Immunology |
Volume | 28 |
Issue number | 3 |
State | Published - 1977 |
Externally published | Yes |