Antibodies against cytomegalovirus induced early antigens (CMV EA) in immunosuppressed renal allograft recipients

T. H. The, H. K. Andersen, E. S. Spencer, G. Klein

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Antibodies against cytomegalovirus-specific early antigens (CMV-EA) were followed in sera, obtained from 15 immunosuppressed renal-allograft recipients. 8 patients (62 sera) showed seroconversion 47-137 days post-transplantation. 5 patients (40 sera) with CMV antibodies at the moment of renal implantation all showed CMV-EA antibody rises. Two patients remained seronegative until 4 years after transplantation. Thus, in immunosuppressed patients, antibodies against CMV-EA remained at high titres during many years (4-8 years) after transplantation as distinct from the apparently transient nature in acutely infected previously healthy adults with CMV mononucleosis or post-perfusion syndrome. These results support the view that CMV-EA antibodies reflect an active viral proliferation in the host.

Original languageEnglish
Pages (from-to)502-505
Number of pages4
JournalClinical and Experimental Immunology
Volume28
Issue number3
StatePublished - 1977
Externally publishedYes

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