@article{2f159cfb6de343f6b4685e0023a1fded,
title = "Anti-VPg antibody inhibition of the poliovirus replicase reaction and production of covalent complexes of VPg-related proteins and RNA",
abstract = "Anti-VPg antibodies inhibited host-factor-dependent RNA synthesis by the poliovirus replicase but not oligo(U)-primed synthesis, implicating VPg in the de novo initiation of replicase products. Complexes of VPg-related polypeptide and newly made RNA could be immunoprecipitated by anti-VPg antibody from the host-factor-stimulated products of the replicase reaction. The complexes appeared to be covalently linked and involved 50 to 150 nucleotide chains of RNA that were RNAase-T1-resistant and could be largely poly(U).",
author = "Baron, {Margaret H.} and David Baltimore",
note = "Funding Information: M. H. B. is a predoctoral scholar of the Insurance Medical Scientist Scholarship Fund and a fellow of the Danforth Foundation. D. 6. is an American Cancer Society Professor of Microbiology. We thank Dr. Andrew Laudano of M. I. T. for generous provision of a control peptide. This research was supported by grants from the National Institute of Allergy and Infectious Disease and from the National Cancer Institute.",
year = "1982",
month = oct,
doi = "10.1016/0092-8674(82)90279-3",
language = "English",
volume = "30",
pages = "745--752",
journal = "Cell",
issn = "0092-8674",
publisher = "Elsevier B.V.",
number = "3",
}