Anti-tumor immunity induced by interleukin-12 gene therapy in a metastic model of breast cancer is mediated by natural killer cells

Keyphrases

• Tumor Immunity 100%
• Interleukin-12 (IL-12) 100%
• Natural Killer Cells 100%
• Gene Therapy 100%
• Breast Cancer 100%
• Long-term Survival 40%
• Metastatic Breast Cancer 40%
• Adenocarcinoma Cells 20%
• Histological Analysis 20%
• Tumor Volume 20%
• Liver 20%
• Antitumor Effect 20%
• Tumor Regression 20%
• Lymphocyte Subsets 20%
• Cell Depletion 20%
• Syngeneic Mice 20%
• Tumor Model 20%
• Tumor Rejection 20%
• Cytokine Therapy 20%
• Inflammatory Changes 20%
• Specific Monoclonal Antibodies 20%
• Intratumoral Administration 20%
• Mammary Adenocarcinoma Cells 20%
• Recombinant Viral Vectors 20%
• Control Vector 20%
• Intrahepatic Tumor 20%
• Nuclear Atypia 20%
• In Vivo Depletion 20%
• Depletion Study 20%
• Direct Inoculation 20%

Immunology and Microbiology

• Natural Killer Cell 100%
• Tumor Immunity 100%
• Interleukin 12 100%
• Long Term Survival 66%
• Syngenic 33%
• Monoclonal Antibody 33%
• Lymphocyte Subpopulation 33%
• Tumor Volume 33%
• Tumor Rejection 33%
• Adenocarcinoma Cell Line 33%
• Adenovirus Vector 33%
• Cytokine Therapy 33%