Anti-tif-1a/g antibody-positive dermatomyositis associated with metastatic prostatic adenocarcinoma

Corinna E. Psomadakis, Samuel Z. Maron, Melissa J. Ng, Alaina J. Kessler, Clare H. Bryce, Vicki L. Shanker, Stephen N. Scelsa

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Dermatomyositis (DM) is an autoimmune myopathy characterized by proximal muscle weakness and distinct skin findings. DM is associated with an increased risk of malignancy in adults. We describe a case of dermatomyositis with unusually severe oropharyngeal dysphagia and respiratory muscle weakness on presentation, who was found to have underlying metastatic prostate cancer. Prostate cancer is uncommonly associated with DM. The patient tested positive for antitranscription intermediate family-1 (anti-TIF-1, also known as anti-p155/410) antibodies, which are linked to malignancy-associated DM in adults and are associated with dysphagia and more severe cutaneous findings.

Original languageEnglish
Pages (from-to)100-104
Number of pages5
JournalJournal of Clinical Neuromuscular Disease
Volume23
Issue number2
DOIs
StatePublished - 1 Dec 2021

Keywords

  • Anti-TIF1
  • Anti-p155
  • Anti-transcription intermediate family-1
  • Antibodies
  • Antip410
  • DM
  • Dermatomyositis
  • Dysphagia
  • Malignancy
  • Paraneoplastic
  • Prostate cancer
  • Proximal myopathy

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