Anti-N-methyl-D-aspartate receptor encephalitis during pregnancy

Monisha A. Kumar, Ankit Jain, Valerie E. Dechant, Tsukasa Saito, Timothy Rafael, Hitoshi Aizawa, Kevin C. Dysart, Takayuki Katayama, Yasuo Ito, Nobuo Araki, Tatsuya Abe, Rita Balice-Gordon, Josep Dalmau

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

Objective: To report 3 patients who developed anti-N-methyl-D-aspartate receptor encephalitis during pregnancy. Design: Case reports. Setting: University hospitals. Patients: Three young women developed at 14, 8, and 17 weeks of gestation acute change of behavior, prominent psychiatric symptoms, progressive decrease of consciousness, seizures, dyskinesias, and autonomic dysfunction. Main Outcome Measures: Clinical, radiological, and immunological findings. Results: The 3 patients had cerebrospinal fluid pleocytosis, normal magnetic resonance imaging, and electroencephalogram showing slow activity. All had higher antibody titers in cerebrospinal fluid than in serum and 2 had ovarian teratomas that were removed. The pregnancy was terminated in 1 patient with recurrent bilateral teratomas. All patients had substantial neurological recoveries, and the 2 newborns were normal. Results of extensive antibody testing in 1 of the babies were negative. Conclusion: The current study shows that anti-NMDAR encephalitis during pregnancy can have a good outcome for the mother and newborn.

Original languageEnglish
Pages (from-to)884-887
Number of pages4
JournalArchives of Neurology
Volume67
Issue number7
DOIs
StatePublished - Jul 2010
Externally publishedYes

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