Anti-HLA antibodies in heart transplantation

Elena R. Vasilescu; Eric K. Ho; Ludwika De La Torre; Silviu Itescu; Charles Marboe; Raffaello Cortesini; Nicole Suciu-Foca; Donna Mancini

doi:10.1016/j.trim.2003.08.002

Anti-HLA antibodies in heart transplantation

Elena R. Vasilescu
, Eric K. Ho
, Ludwika De La Torre
, Silviu Itescu
, Charles Marboe
, Raffaello Cortesini
, Nicole Suciu-Foca
, Donna Mancini

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

We have analyzed the relationship between the development of transplant-related coronary artery disease (TRCAD) and the following potential risk factors: (a) number of HLA mismatches between recipient and donor; (b) production of anti-HLA antibodies; (c) growth of lymphocytes infiltrating the graft; and (d) frequency of biopsy proven episodes of acute rejection. The study population consisted of 285 adult heart allograft recipients who were monitored over a period of two years or more. The results demonstrate a significant correlation between TRCAD, generation of anti-HLA class II antibodies and potential of lymphocytes infiltrating the graft to proliferate ex-vivo in medium containing IL-2. Humoral and cellular immune responses to HLA-DR antigens expressed by the graft seem to underlie the development of TRCAD.

Original language	English
Pages (from-to)	177-183
Number of pages	7
Journal	Transplant Immunology
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/j.trim.2003.08.002
State	Published - Jan 2004
Externally published	Yes

Keywords

HLA antibodies
Heart transplantation
Transplant-related coronary artery disease

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10.1016/j.trim.2003.08.002

Cite this

@article{e426547030a74045956649bf9d065d6f,

title = "Anti-HLA antibodies in heart transplantation",

abstract = "We have analyzed the relationship between the development of transplant-related coronary artery disease (TRCAD) and the following potential risk factors: (a) number of HLA mismatches between recipient and donor; (b) production of anti-HLA antibodies; (c) growth of lymphocytes infiltrating the graft; and (d) frequency of biopsy proven episodes of acute rejection. The study population consisted of 285 adult heart allograft recipients who were monitored over a period of two years or more. The results demonstrate a significant correlation between TRCAD, generation of anti-HLA class II antibodies and potential of lymphocytes infiltrating the graft to proliferate ex-vivo in medium containing IL-2. Humoral and cellular immune responses to HLA-DR antigens expressed by the graft seem to underlie the development of TRCAD.",

keywords = "HLA antibodies, Heart transplantation, Transplant-related coronary artery disease",

author = "Vasilescu, \{Elena R.\} and Ho, \{Eric K.\} and \{De La Torre\}, Ludwika and Silviu Itescu and Charles Marboe and Raffaello Cortesini and Nicole Suciu-Foca and Donna Mancini",

note = "Funding Information: This work was supported by grants from the NIH (AI25210-17 and AI55234-01) and the Interuniversitary Organ Transplantation Consortium, Rome, Italy.",

year = "2004",

month = jan,

doi = "10.1016/j.trim.2003.08.002",

language = "English",

volume = "12",

pages = "177--183",

journal = "Transplant Immunology",

issn = "0966-3274",

publisher = "Elsevier B.V.",

number = "2",

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TY - JOUR

T1 - Anti-HLA antibodies in heart transplantation

AU - Vasilescu, Elena R.

AU - Ho, Eric K.

AU - De La Torre, Ludwika

AU - Itescu, Silviu

AU - Marboe, Charles

AU - Cortesini, Raffaello

AU - Suciu-Foca, Nicole

AU - Mancini, Donna

N1 - Funding Information: This work was supported by grants from the NIH (AI25210-17 and AI55234-01) and the Interuniversitary Organ Transplantation Consortium, Rome, Italy.

PY - 2004/1

Y1 - 2004/1

N2 - We have analyzed the relationship between the development of transplant-related coronary artery disease (TRCAD) and the following potential risk factors: (a) number of HLA mismatches between recipient and donor; (b) production of anti-HLA antibodies; (c) growth of lymphocytes infiltrating the graft; and (d) frequency of biopsy proven episodes of acute rejection. The study population consisted of 285 adult heart allograft recipients who were monitored over a period of two years or more. The results demonstrate a significant correlation between TRCAD, generation of anti-HLA class II antibodies and potential of lymphocytes infiltrating the graft to proliferate ex-vivo in medium containing IL-2. Humoral and cellular immune responses to HLA-DR antigens expressed by the graft seem to underlie the development of TRCAD.

AB - We have analyzed the relationship between the development of transplant-related coronary artery disease (TRCAD) and the following potential risk factors: (a) number of HLA mismatches between recipient and donor; (b) production of anti-HLA antibodies; (c) growth of lymphocytes infiltrating the graft; and (d) frequency of biopsy proven episodes of acute rejection. The study population consisted of 285 adult heart allograft recipients who were monitored over a period of two years or more. The results demonstrate a significant correlation between TRCAD, generation of anti-HLA class II antibodies and potential of lymphocytes infiltrating the graft to proliferate ex-vivo in medium containing IL-2. Humoral and cellular immune responses to HLA-DR antigens expressed by the graft seem to underlie the development of TRCAD.

KW - HLA antibodies

KW - Heart transplantation

KW - Transplant-related coronary artery disease

UR - https://www.scopus.com/pages/publications/1242351543

U2 - 10.1016/j.trim.2003.08.002

DO - 10.1016/j.trim.2003.08.002

M3 - Article

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AN - SCOPUS:1242351543

SN - 0966-3274

VL - 12

SP - 177

EP - 183

JO - Transplant Immunology

JF - Transplant Immunology

IS - 2

ER -

Anti-HLA antibodies in heart transplantation

Abstract

Keywords

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