Anti-Fc-Receptor Therapy of Refractory Immune Thrombocytopenic Purpura

S. Ray Mitchell; Gail Whalen; Thomas R. Cupps; Paul Katz; Sarah B. Clarkson; James B. Bussel; Robert P. Kimberly; Jay E. Valinsky; Ralph L. Nachman; Jay C. Unkeless

doi:10.1056/NEJM198611063151917

Anti-Fc-Receptor Therapy of Refractory Immune Thrombocytopenic Purpura

S. Ray Mitchell, Gail Whalen, Thomas R. Cupps, Paul Katz, Sarah B. Clarkson, James B. Bussel, Robert P. Kimberly, Jay E. Valinsky, Ralph L. Nachman, Jay C. Unkeless

Research output: Contribution to journal › Letter › peer-review

1 Scopus citations

Abstract

To the Editor: The report in the May 8 issue¹ on monoclonal antibody therapy for refractory immune thrombocytopenic purpura adds to the observation that polyclonal intravenous gamma globulin decreases the cytotoxic activity, as well as the phenotypic presence, of natural killer (NK) cells in the circulation.² However, this study failed to consider the phenotypic as well as functional heterogeneity of the NK-cell population. The choice of the monoclonal antibody anti-Leu 7 (HNK-1) as an indicator of the quantitative NK-cell population, as well as a functional parallel of cytotoxic activity, is less than optimal. Anti-Leu 7 is a non-Fc-directed monoclonal antibody.

Original language	English
Pages (from-to)	1230-1231
Number of pages	2
Journal	New England Journal of Medicine
Volume	315
Issue number	19
DOIs	https://doi.org/10.1056/NEJM198611063151917
State	Published - 6 Nov 1986
Externally published	Yes

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title = "Anti-Fc-Receptor Therapy of Refractory Immune Thrombocytopenic Purpura",

abstract = "To the Editor: The report in the May 8 issue1 on monoclonal antibody therapy for refractory immune thrombocytopenic purpura adds to the observation that polyclonal intravenous gamma globulin decreases the cytotoxic activity, as well as the phenotypic presence, of natural killer (NK) cells in the circulation.2 However, this study failed to consider the phenotypic as well as functional heterogeneity of the NK-cell population. The choice of the monoclonal antibody anti-Leu 7 (HNK-1) as an indicator of the quantitative NK-cell population, as well as a functional parallel of cytotoxic activity, is less than optimal. Anti-Leu 7 is a non-Fc-directed monoclonal antibody.",

author = "Mitchell, {S. Ray} and Gail Whalen and Cupps, {Thomas R.} and Paul Katz and Clarkson, {Sarah B.} and Bussel, {James B.} and Kimberly, {Robert P.} and Valinsky, {Jay E.} and Nachman, {Ralph L.} and Unkeless, {Jay C.}",

year = "1986",

month = nov,

day = "6",

doi = "10.1056/NEJM198611063151917",

language = "English",

volume = "315",

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TY - JOUR

T1 - Anti-Fc-Receptor Therapy of Refractory Immune Thrombocytopenic Purpura

AU - Mitchell, S. Ray

AU - Whalen, Gail

AU - Cupps, Thomas R.

AU - Katz, Paul

AU - Clarkson, Sarah B.

AU - Bussel, James B.

AU - Kimberly, Robert P.

AU - Valinsky, Jay E.

AU - Nachman, Ralph L.

AU - Unkeless, Jay C.

PY - 1986/11/6

Y1 - 1986/11/6

N2 - To the Editor: The report in the May 8 issue1 on monoclonal antibody therapy for refractory immune thrombocytopenic purpura adds to the observation that polyclonal intravenous gamma globulin decreases the cytotoxic activity, as well as the phenotypic presence, of natural killer (NK) cells in the circulation.2 However, this study failed to consider the phenotypic as well as functional heterogeneity of the NK-cell population. The choice of the monoclonal antibody anti-Leu 7 (HNK-1) as an indicator of the quantitative NK-cell population, as well as a functional parallel of cytotoxic activity, is less than optimal. Anti-Leu 7 is a non-Fc-directed monoclonal antibody.

AB - To the Editor: The report in the May 8 issue1 on monoclonal antibody therapy for refractory immune thrombocytopenic purpura adds to the observation that polyclonal intravenous gamma globulin decreases the cytotoxic activity, as well as the phenotypic presence, of natural killer (NK) cells in the circulation.2 However, this study failed to consider the phenotypic as well as functional heterogeneity of the NK-cell population. The choice of the monoclonal antibody anti-Leu 7 (HNK-1) as an indicator of the quantitative NK-cell population, as well as a functional parallel of cytotoxic activity, is less than optimal. Anti-Leu 7 is a non-Fc-directed monoclonal antibody.

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M3 - Letter

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JO - New England Journal of Medicine

JF - New England Journal of Medicine

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ER -

Anti-Fc-Receptor Therapy of Refractory Immune Thrombocytopenic Purpura

Abstract

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