TY - JOUR
T1 - Anterior insular cortex is a bottleneck of cognitive control
AU - Wu, Tingting
AU - Wang, Xingchao
AU - Wu, Qiong
AU - Spagna, Alfredo
AU - Yang, Jiaqi
AU - Yuan, Changhe
AU - Wu, Yanhong
AU - Gao, Zhixian
AU - Hof, Patrick R.
AU - Fan, Jin
N1 - Funding Information:
We thank Dr. Thomas Lee for helping discuss the design and piloting of the task, Mr. Alexander J. Dufford for helping in collection of fMRI data, Mr. Cong Chen for helping in the Bayesian network analyses, and Ms. Liat Kofler for helping proof reading. Research reported in this publication was supported by the National Institute of Mental Health of the National Institutes of Health under Award Number R01 MH094305. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. This study was also supported by the National Natural Science Foundation of China (grant numbers: 81328008 and 81729001). The research of J.F. and T.W. is also partially supported by the grant NSF IIS 1718802. X.W. was supported by the National Natural Science Foundation of China (grant numbers: 81600931)and Beijing Municipal Administration of Hospitals’ Youth Program (code: QML20170503).
Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/7/15
Y1 - 2019/7/15
N2 - Cognitive control, with a limited capacity, is a core process in human cognition for the coordination of thoughts and actions. Although the regions involved in cognitive control have been identified as the cognitive control network (CCN), it is still unclear whether a specific region of the CCN serves as a bottleneck limiting the capacity of cognitive control (CCC). Here, we used a perceptual decision-making task with conditions of high cognitive load to challenge the CCN and to assess the CCC in a functional magnetic resonance imaging study. We found that the activation of the right anterior insular cortex (AIC)of the CCN increased monotonically as a function of cognitive load, reached its plateau early, and showed a significant correlation to the CCC. In a subsequent study of patients with unilateral lesions of the AIC, we found that lesions of the AIC were associated with a significant impairment of the CCC. Simulated lesions of the AIC resulted in a reduction of the global efficiency of the CCN in a network analysis. These findings suggest that the AIC, as a critical hub in the CCN, is a bottleneck of cognitive control.
AB - Cognitive control, with a limited capacity, is a core process in human cognition for the coordination of thoughts and actions. Although the regions involved in cognitive control have been identified as the cognitive control network (CCN), it is still unclear whether a specific region of the CCN serves as a bottleneck limiting the capacity of cognitive control (CCC). Here, we used a perceptual decision-making task with conditions of high cognitive load to challenge the CCN and to assess the CCC in a functional magnetic resonance imaging study. We found that the activation of the right anterior insular cortex (AIC)of the CCN increased monotonically as a function of cognitive load, reached its plateau early, and showed a significant correlation to the CCC. In a subsequent study of patients with unilateral lesions of the AIC, we found that lesions of the AIC were associated with a significant impairment of the CCC. Simulated lesions of the AIC resulted in a reduction of the global efficiency of the CCN in a network analysis. These findings suggest that the AIC, as a critical hub in the CCN, is a bottleneck of cognitive control.
KW - Anterior cingulate cortex
KW - Anterior insular cortex
KW - Cognitive control
KW - Cognitive control capacity
KW - Cognitive control network
UR - http://www.scopus.com/inward/record.url?scp=85064736503&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2019.02.042
DO - 10.1016/j.neuroimage.2019.02.042
M3 - Article
C2 - 30798012
AN - SCOPUS:85064736503
SN - 1053-8119
VL - 195
SP - 490
EP - 504
JO - NeuroImage
JF - NeuroImage
ER -