Anterior cingulate volumetric alterations in treatment-naïve adults with ADHD: A pilot study

Nikos Makris, Larry J. Seidman, Eve M. Valera, Joseph Biederman, Michael C. Monuteaux, David N. Kennedy, Verne S. Caviness, George Bush, Katherine Crum, Ariel B. Brown, Stephen V. Faraone

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Objective: We sought to examine preliminary results of brain alterations in anterior cingulate cortex (ACC) in treatment-naïve adults with ADHD. The ACC is a central brain node for the integration of cognitive control and allocation of attention, affect and drive. Thus its anatomical alteration may give rise to impulsivity, hyperactivity and inattention, which are cardinal behavioral manifestations of ADHD. Method: Segmentation and parcellation of the ACC was performed on controls (n = 22), treated (n = 13) and treatment-naïve adults with ADHD (n = 13). Results: There was a 21% volume reduction in the left ACC of the treatment-naïve group relative to the control group. Also, there was a 23% volume reduction in the right ACC of the treated group relative to the control group. Conclusion: These results raise the possibility that in ADHD there are volumetric deficits persistent into adulthood, that are independent of medical treatment. (J. of Att. Dis. 2010; 13(4) 407-413).

Original languageEnglish
Pages (from-to)407-413
Number of pages7
JournalJournal of Attention Disorders
Issue number4
StatePublished - Jan 2010
Externally publishedYes


  • ACC
  • ADHD
  • MRI
  • Morphometry
  • Treatment-naïve ADHD
  • Volumetry


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