Anterior cingulate volumetric alterations in treatment-naïve adults with ADHD: A pilot study

Nikos Makris; Larry J. Seidman; Eve M. Valera; Joseph Biederman; Michael C. Monuteaux; David N. Kennedy; Verne S. Caviness; George Bush; Katherine Crum; Ariel B. Brown; Stephen V. Faraone

doi:10.1177/1087054709351671

Anterior cingulate volumetric alterations in treatment-naïve adults with ADHD: A pilot study

Nikos Makris, Larry J. Seidman, Eve M. Valera, Joseph Biederman, Michael C. Monuteaux, David N. Kennedy, Verne S. Caviness, George Bush, Katherine Crum, Ariel B. Brown, Stephen V. Faraone

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Objective: We sought to examine preliminary results of brain alterations in anterior cingulate cortex (ACC) in treatment-naïve adults with ADHD. The ACC is a central brain node for the integration of cognitive control and allocation of attention, affect and drive. Thus its anatomical alteration may give rise to impulsivity, hyperactivity and inattention, which are cardinal behavioral manifestations of ADHD. Method: Segmentation and parcellation of the ACC was performed on controls (n = 22), treated (n = 13) and treatment-naïve adults with ADHD (n = 13). Results: There was a 21% volume reduction in the left ACC of the treatment-naïve group relative to the control group. Also, there was a 23% volume reduction in the right ACC of the treated group relative to the control group. Conclusion: These results raise the possibility that in ADHD there are volumetric deficits persistent into adulthood, that are independent of medical treatment. (J. of Att. Dis. 2010; 13(4) 407-413).

Original language	English
Pages (from-to)	407-413
Number of pages	7
Journal	Journal of Attention Disorders
Volume	13
Issue number	4
DOIs	https://doi.org/10.1177/1087054709351671
State	Published - Jan 2010
Externally published	Yes

Keywords

ACC
ADHD
MRI
Morphometry
Treatment-naïve ADHD
Volumetry

Access to Document

10.1177/1087054709351671

Cite this

@article{69741e82daa541a9906e20c4eb6de833,

title = "Anterior cingulate volumetric alterations in treatment-na{\"i}ve adults with ADHD: A pilot study",

abstract = "Objective: We sought to examine preliminary results of brain alterations in anterior cingulate cortex (ACC) in treatment-na{\"i}ve adults with ADHD. The ACC is a central brain node for the integration of cognitive control and allocation of attention, affect and drive. Thus its anatomical alteration may give rise to impulsivity, hyperactivity and inattention, which are cardinal behavioral manifestations of ADHD. Method: Segmentation and parcellation of the ACC was performed on controls (n = 22), treated (n = 13) and treatment-na{\"i}ve adults with ADHD (n = 13). Results: There was a 21% volume reduction in the left ACC of the treatment-na{\"i}ve group relative to the control group. Also, there was a 23% volume reduction in the right ACC of the treated group relative to the control group. Conclusion: These results raise the possibility that in ADHD there are volumetric deficits persistent into adulthood, that are independent of medical treatment. (J. of Att. Dis. 2010; 13(4) 407-413).",

keywords = "ACC, ADHD, MRI, Morphometry, Treatment-na{\"i}ve ADHD, Volumetry",

author = "Nikos Makris and Seidman, {Larry J.} and Valera, {Eve M.} and Joseph Biederman and Monuteaux, {Michael C.} and Kennedy, {David N.} and Caviness, {Verne S.} and George Bush and Katherine Crum and Brown, {Ariel B.} and Faraone, {Stephen V.}",

year = "2010",

month = jan,

doi = "10.1177/1087054709351671",

language = "English",

volume = "13",

pages = "407--413",

journal = "Journal of Attention Disorders",

issn = "1087-0547",

publisher = "SAGE Publications Inc.",

number = "4",

}

TY - JOUR

T1 - Anterior cingulate volumetric alterations in treatment-naïve adults with ADHD

T2 - A pilot study

AU - Makris, Nikos

AU - Seidman, Larry J.

AU - Valera, Eve M.

AU - Biederman, Joseph

AU - Monuteaux, Michael C.

AU - Kennedy, David N.

AU - Caviness, Verne S.

AU - Bush, George

AU - Crum, Katherine

AU - Brown, Ariel B.

AU - Faraone, Stephen V.

PY - 2010/1

Y1 - 2010/1

N2 - Objective: We sought to examine preliminary results of brain alterations in anterior cingulate cortex (ACC) in treatment-naïve adults with ADHD. The ACC is a central brain node for the integration of cognitive control and allocation of attention, affect and drive. Thus its anatomical alteration may give rise to impulsivity, hyperactivity and inattention, which are cardinal behavioral manifestations of ADHD. Method: Segmentation and parcellation of the ACC was performed on controls (n = 22), treated (n = 13) and treatment-naïve adults with ADHD (n = 13). Results: There was a 21% volume reduction in the left ACC of the treatment-naïve group relative to the control group. Also, there was a 23% volume reduction in the right ACC of the treated group relative to the control group. Conclusion: These results raise the possibility that in ADHD there are volumetric deficits persistent into adulthood, that are independent of medical treatment. (J. of Att. Dis. 2010; 13(4) 407-413).

AB - Objective: We sought to examine preliminary results of brain alterations in anterior cingulate cortex (ACC) in treatment-naïve adults with ADHD. The ACC is a central brain node for the integration of cognitive control and allocation of attention, affect and drive. Thus its anatomical alteration may give rise to impulsivity, hyperactivity and inattention, which are cardinal behavioral manifestations of ADHD. Method: Segmentation and parcellation of the ACC was performed on controls (n = 22), treated (n = 13) and treatment-naïve adults with ADHD (n = 13). Results: There was a 21% volume reduction in the left ACC of the treatment-naïve group relative to the control group. Also, there was a 23% volume reduction in the right ACC of the treated group relative to the control group. Conclusion: These results raise the possibility that in ADHD there are volumetric deficits persistent into adulthood, that are independent of medical treatment. (J. of Att. Dis. 2010; 13(4) 407-413).

KW - ACC

KW - ADHD

KW - MRI

KW - Morphometry

KW - Treatment-naïve ADHD

KW - Volumetry

UR - http://www.scopus.com/inward/record.url?scp=72149105317&partnerID=8YFLogxK

U2 - 10.1177/1087054709351671

DO - 10.1177/1087054709351671

M3 - Article

C2 - 20008822

AN - SCOPUS:72149105317

SN - 1087-0547

VL - 13

SP - 407

EP - 413

JO - Journal of Attention Disorders

JF - Journal of Attention Disorders

IS - 4

ER -

Anterior cingulate volumetric alterations in treatment-naïve adults with ADHD: A pilot study

Abstract

Keywords

Access to Document

Fingerprint

Cite this