ANTENATAL DIAGNOSIS OF NEURAL-TUBE DEFECTS USING CEREBROSPINAL-FLUID PROTEINS

James N. Macri; Mahdusudan S. Joshi; Robert R. Weiss; Mark I. Evans

doi:10.1016/S0140-6736(74)93002-5

ANTENATAL DIAGNOSIS OF NEURAL-TUBE DEFECTS USING CEREBROSPINAL-FLUID PROTEINS

James N. Macri
, Mahdusudan S. Joshi
, Robert R. Weiss
, Mark I. Evans

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Diagnosis of an anencephalic fetus has been confirmed by immunological detection of β-trace protein of cerebrospinal fluid in amniotic fluid. In seventy-five control amniotic-fluid samples, a precipitin reaction to β-trace protein could not be demonstrated. It is suggested that this method may serve as a reliable specific index of neural-tube defects.

Original language	English
Pages (from-to)	14-15
Number of pages	2
Journal	The Lancet
Volume	303
Issue number	7845
DOIs	https://doi.org/10.1016/S0140-6736(74)93002-5
State	Published - 5 Jan 1974
Externally published	Yes

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@article{fdfe24b4732e4a169bc9eaa0639f3dc4,

title = "ANTENATAL DIAGNOSIS OF NEURAL-TUBE DEFECTS USING CEREBROSPINAL-FLUID PROTEINS",

abstract = "Diagnosis of an anencephalic fetus has been confirmed by immunological detection of β-trace protein of cerebrospinal fluid in amniotic fluid. In seventy-five control amniotic-fluid samples, a precipitin reaction to β-trace protein could not be demonstrated. It is suggested that this method may serve as a reliable specific index of neural-tube defects.",

author = "Macri, \{James N.\} and Joshi, \{Mahdusudan S.\} and Weiss, \{Robert R.\} and Evans, \{Mark I.\}",

note = "Funding Information: This work was part of a continuing combined study on intracellular electrolytes in cardiac disease, with Mr M. V. Braimbridge and Mr D. G. Hill. J. P. was supported by the Medical Research Council and N. F. J. by the endowment fund of St. Thomas{\textquoteright}s Hospital and the National Kidney Research Fund. We thank Mrs A. Evans for expert assistance.",

year = "1974",

month = jan,

day = "5",

doi = "10.1016/S0140-6736(74)93002-5",

language = "English",

volume = "303",

pages = "14--15",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier B.V.",

number = "7845",

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TY - JOUR

T1 - ANTENATAL DIAGNOSIS OF NEURAL-TUBE DEFECTS USING CEREBROSPINAL-FLUID PROTEINS

AU - Macri, James N.

AU - Joshi, Mahdusudan S.

AU - Weiss, Robert R.

AU - Evans, Mark I.

N1 - Funding Information: This work was part of a continuing combined study on intracellular electrolytes in cardiac disease, with Mr M. V. Braimbridge and Mr D. G. Hill. J. P. was supported by the Medical Research Council and N. F. J. by the endowment fund of St. Thomas’s Hospital and the National Kidney Research Fund. We thank Mrs A. Evans for expert assistance.

PY - 1974/1/5

Y1 - 1974/1/5

N2 - Diagnosis of an anencephalic fetus has been confirmed by immunological detection of β-trace protein of cerebrospinal fluid in amniotic fluid. In seventy-five control amniotic-fluid samples, a precipitin reaction to β-trace protein could not be demonstrated. It is suggested that this method may serve as a reliable specific index of neural-tube defects.

AB - Diagnosis of an anencephalic fetus has been confirmed by immunological detection of β-trace protein of cerebrospinal fluid in amniotic fluid. In seventy-five control amniotic-fluid samples, a precipitin reaction to β-trace protein could not be demonstrated. It is suggested that this method may serve as a reliable specific index of neural-tube defects.

UR - https://www.scopus.com/pages/publications/0015972165

U2 - 10.1016/S0140-6736(74)93002-5

DO - 10.1016/S0140-6736(74)93002-5

M3 - Article

C2 - 4128991

AN - SCOPUS:0015972165

SN - 0140-6736

VL - 303

SP - 14

EP - 15

JO - The Lancet

JF - The Lancet

IS - 7845

ER -

ANTENATAL DIAGNOSIS OF NEURAL-TUBE DEFECTS USING CEREBROSPINAL-FLUID PROTEINS

Abstract

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