TY - JOUR
T1 - Antenatal depressive symptoms and adverse perinatal outcomes
AU - Pampaka, Despina
AU - Papatheodorou, Stefania I.
AU - AlSeaidan, Mohammad
AU - Al Wotayan, Rihab
AU - Wright, Rosalind J.
AU - Buring, Julie E.
AU - Dockery, Douglas W.
AU - Christophi, Costas A.
N1 - Funding Information:
The TRACER study was supported by the Dasman Institute for Diabetes Research and the Kuwait Ministry of Health. We would also like to thank the administration and clinical staff at the South Hawalli Clinic, Al-Hakim Clinic, West Farwaniya Clinic, Subah Al Naser Clinic, Jahraa Clinic, Al-Sager Clinic, Al-Qurain Health Clinic, New Mowasat Hospital, and Royale Hayat Hospital. Most of all, we thank the participants of the TRACER study.
Funding Information:
The TRACER study received funding from the Kuwait Foundation for the Advancement of Science.
Funding Information:
The TRACER study was supported by the Dasman Institute for Diabetes Research and the Kuwait Ministry of Health. We would also like to thank the administration and clinical staff at the South Hawalli Clinic, Al-Hakim Clinic, West Farwaniya Clinic, Subah Al Naser Clinic, Jahraa Clinic, Al-Sager Clinic, Al-Qurain Health Clinic, New Mowasat Hospital, and Royale Hayat Hospital. Most of all, we thank the participants of the TRACER study.
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Background: The association of antenatal depression with adverse pregnancy, birth, and postnatal outcomes has been an item of scientific interest over the last decades. However, the evidence that exists is controversial or limited. We previously found that one in five women in Kuwait experience antenatal depressive symptoms. Therefore, the aim of this study was to examine whether antenatal depressive symptoms are associated with preterm birth (PTB), small for gestational age (SGA), or large for gestational age (LGA) babies in this population. Methods: This was a secondary analysis based on data collected in the Transgenerational Assessment of Children’s Environmental Risk (TRACER) Study that was conducted in Kuwait. Logistic regression analysis was used to examine whether antenatal depressive symptoms assessed using the Edinburgh Depression Scale (EDS) were associated with preterm birth, small for gestational age, and large for gestational age babies. Results: A total of 1694 women had complete information about the outcomes of interest. Women with depressive symptoms in pregnancy had increased, albeit non-significant, odds of having PTB (OR = 1.41; 95%CI: 0.81, 2.45), SGA babies (OR = 1.26; 0.80, 1.98), or LGA babies (OR = 1.27; 0.90, 1.79). Antenatal depressive symptoms had similar increased odds for the three outcomes even after adjusting for several covariates though none of these reached statistical significance. Conclusions: In the present study, the depressive symptoms in pregnancy did not predict adverse birth outcomes, such as PTB, SGA, and LGA, which adds to the currently non-conclusive literature. However, further research is needed to examine these associations, as the available evidence is quite limited.
AB - Background: The association of antenatal depression with adverse pregnancy, birth, and postnatal outcomes has been an item of scientific interest over the last decades. However, the evidence that exists is controversial or limited. We previously found that one in five women in Kuwait experience antenatal depressive symptoms. Therefore, the aim of this study was to examine whether antenatal depressive symptoms are associated with preterm birth (PTB), small for gestational age (SGA), or large for gestational age (LGA) babies in this population. Methods: This was a secondary analysis based on data collected in the Transgenerational Assessment of Children’s Environmental Risk (TRACER) Study that was conducted in Kuwait. Logistic regression analysis was used to examine whether antenatal depressive symptoms assessed using the Edinburgh Depression Scale (EDS) were associated with preterm birth, small for gestational age, and large for gestational age babies. Results: A total of 1694 women had complete information about the outcomes of interest. Women with depressive symptoms in pregnancy had increased, albeit non-significant, odds of having PTB (OR = 1.41; 95%CI: 0.81, 2.45), SGA babies (OR = 1.26; 0.80, 1.98), or LGA babies (OR = 1.27; 0.90, 1.79). Antenatal depressive symptoms had similar increased odds for the three outcomes even after adjusting for several covariates though none of these reached statistical significance. Conclusions: In the present study, the depressive symptoms in pregnancy did not predict adverse birth outcomes, such as PTB, SGA, and LGA, which adds to the currently non-conclusive literature. However, further research is needed to examine these associations, as the available evidence is quite limited.
KW - Adverse perinatal outcomes
KW - Antenatal depressive symptoms
KW - Kuwait
KW - Large for gestational age
KW - Preterm birth
KW - Small for gestational age
UR - http://www.scopus.com/inward/record.url?scp=85104619782&partnerID=8YFLogxK
U2 - 10.1186/s12884-021-03783-9
DO - 10.1186/s12884-021-03783-9
M3 - Article
C2 - 33879069
AN - SCOPUS:85104619782
VL - 21
JO - BMC Pregnancy and Childbirth
JF - BMC Pregnancy and Childbirth
SN - 1471-2393
IS - 1
M1 - 313
ER -