Antenatal antibiotic exposure in preterm infants with necrotizing enterocolitis

A. S. Weintraub, L. Ferrara, L. Deluca, E. Moshier, R. S. Green, E. Oakman, M. J. Lee, L. Rand

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Objective: To determine whether an association exists between antenatal antibiotic exposure and incidence of necrotizing enterocolitis (NEC) in low birth weight infants. Study Design: A retrospective case-control study was performed on all infants with a diagnosis of NEC born at our institition between 1988 and 2006. Medical histories of all infants with a diagnosis of NEC ≤Bell's stage IIA and matched controls without NEC were reviewed. Maternal and neonatal characteristics were compared using the Mantel-Haenszel chi-square procedure, and logistic regression models were constructed to account for confounding. Result: Clinical data for 97 matched pairs were analyzed. The adjusted odds ratio (OR) for antenatal exposure to ampicillin was significantly greater for infants who developed NEC (OR 2.3, 95% confidence interval 1.1, 4.8, P=0.003) than for control infants. Conclusion: Infants who developed NEC were more likely to have a history of in utero exposure to ampicillin in the immediate antepartum period than infants who did not develop NEC.

Original languageEnglish
Pages (from-to)705-709
Number of pages5
JournalJournal of Perinatology
Issue number9
StatePublished - Sep 2012


  • ampicillin
  • low birth weight
  • necrotizing enterocolitis


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