Another fork in the road - Life or death decisions by the tumour suppressor p53

Luis A. Carvajal, James J. Manfredi

Research output: Contribution to journalReview articlepeer-review

119 Scopus citations

Abstract

In response to cellular stress signals, the tumour suppressor p53 accumulates and triggers a host of antineoplastic responses. For instance, DNA damage activates two main p53-dependent responses: cell cycle arrest and attendant DNA repair or apoptosis (cell death). It is broadly accepted that, in response to DNA damage, the function of p53 as a sequence-specific transcription factor is crucial for tumour suppression. The molecular determinants, however, that favour the initiation of either a p53-dependent cell cycle arrest (life) or apoptotic (death) transcriptional programme remain elusive. Gaining a clear understanding of the mechanisms controlling cell fate determination by p53 could lead to the identification of molecular targets for therapy, which could selectively sensitize cancer cells to apoptosis. This review summarizes the literature addressing this important question in the field. Special emphasis is given to the role of the p53 response element, post-translational modifications and protein-protein interactions on cell fate decisions made by p53 in response to DNA damage.

Original languageEnglish
Pages (from-to)414-421
Number of pages8
JournalEMBO Reports
Volume14
Issue number5
DOIs
StatePublished - May 2013

Keywords

  • apoptosis
  • cell cycle arrest
  • cellular stress
  • p53
  • transcription

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