Eating disorders, including anorexia nervosa and bulimia nervosa, have long been recognized in psychiatry and other medical disciplines for their primary dysregulation in the basic ability to eat and inability to maintain weight without significant distress or dysregulation. Although the diagnostic criteria of these disorders have been debated over time, the core feature remain as (1) disturbances in the ability to maintain a healthy weight, (2) recurrent binge-eating or compensatory behavior, and (3) significant disturbances in the investment and perceptions of shape, weight, or appearance. The neurobiology of these disorders has been aided greatly by the study of eating behavior and weight regulation designed to study obesity. This chapter summarizes the current state of knowledge about the genetic, hormonal, neurotransmitter, and functional neurocircuitry of these disorders. Emerging evidence suggests that appetite hormones and peptides, adrenal hormones, ovarian hormones, and serotonin and dopamine are dysregulated in both disorders. Despite these advances, no neurobiological model has been able to explain the differences in prevalence rates between men and women or the common occurrence of expression during puberty. It is likely that relevant hormonal systems and neurotransmitter changes are working synergistically to affect these disorders. Future directions in translational and clinical research are discussed.

Original languageEnglish
Title of host publicationNeuroscience in the 21st Century
Subtitle of host publicationFrom Basic to Clinical: Third Edition
PublisherSpringer International Publishing
Number of pages27
ISBN (Electronic)9783030888329
ISBN (Print)9783030888312
StatePublished - 1 Jan 2022


  • Adiponectin
  • Anorexia nervosa
  • Bulimia nervosa
  • Cognitive-limbic neurocircuits
  • Description
  • Development vs. maintenance
  • Developmental model
  • Diagnostic criteria
  • Dopaminergic (DA) systems
  • Dorsolateral prefrontal cortex (DLPC)
  • Dysregulaion in hormonal systems
  • Dysregulation in hormonal systems
  • Endocannabinoid (eCB) system
  • Gender differences
  • Genetic vulnerability
  • Ghrelin
  • Kynorexia
  • Leptin
  • Neurobiological models
  • Neurocircuitry
  • Neuropeptide Y
  • Neurotransmitter dysregulation
  • Neurotransmitter regulation
  • Ovarian hormones
  • Peptide YY
  • Pituitary cachexia
  • Prenatal riskl
  • Simmonds disease
  • Starvation vs. psychopathology
  • Temperament
  • Thyrotropin-releasing hormone


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