@article{725f5a7030464b879f63db341888fe3e,
title = "Anomalous amygdala habituation to unpleasant stimuli among unmedicated individuals with borderline personality disorder and a history of self-harming behavior",
abstract = "Self-harming behavior (SB) is one of the diagnostic criteria for borderline personality disorder (BPD). However, it is not exhibited by all individuals with BPD. Furthermore, studies examining the neural correlates of SB in BPD are lacking. Given research showing that BPD patients have difficulty habituating to affective stimuli, this study investigated whether anomalous amygdala activation is specific to BPD patients with SB. The authors used fMRI to compare amygdala activation in BPD patients with SB (n = 15) to BPD patients without SB (n = 18) and healthy controls (n = 32) during a task involving pleasant, neutral, and unpleasant pictures, presented twice. BPD patients with SB demonstrated greater amygdala activity during the second presentation of unpleasant pictures. Results highlight neurobiological differences in BPD patients with and without SB and suggest that anomalous amygdala habituation to unpleasant stimuli may be related to SB.",
keywords = "Amygdala, Borderline personality disorder, Emotion, FMRI, Self-harming behavior",
author = "Goldstein, {Kim E.} and Abigail Feinberg and Corniquel, {Morgan B.} and Szeszko, {Jake R.} and New, {Antonia S.} and Haznedar, {M. Mehmet} and Marianne Goodman and Chu, {King Wai} and Tang, {Cheuk Y.} and Hazlett, {Erin A.}",
note = "Funding Information: From Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York (K. E. G., A. F., M. B. C., J. R. S., A. S. N., M. M. H., M. G., E. A. H.); Mental Illness Research, Education, and Clinical Center (MIRECC VISN 2), James J. Peters VA Medical Center, Bronx, New York (K. E. G., A. F., J. R. S., M. G., K.-W. C., E. A. H.); Mental Health Patient Care Center, James J. Peters Veterans Affairs Medical Center (M. M. H.); and Translational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai (C. Y. T.). This work was supported by NIMH grant R01MH073911 and VA Research Center Scientist Award 1 lK6 CX001738 to Dr. Hazlett. None of the authors have any conflicts of interest. Address correspondence to Kim E. Goldstein, PhD, Mental Illness Research and Clinical Center (MIRECC VISN2), James J. Peters VAMC, 130 W. Kingsbridge Rd., Rm. 4B–46, Bronx, NY 10468. E-mail: kim.zinn@mssm.edu Publisher Copyright: {\textcopyright} 2021 The Guilford Press.",
year = "2021",
month = aug,
doi = "10.1521/pedi_2020_34_495",
language = "English",
volume = "35",
pages = "618--631",
journal = "Journal of Personality Disorders",
issn = "0885-579X",
publisher = "Guilford Publications",
number = "4",
}