Annexin V SPECT imaging of phosphatidylserine expression in patients with dementia

Y. Lampl; M. Lorberboym; F. G. Blankenberg; M. Sadeh; R. Gilad

doi:10.1212/01.wnl.0000208436.75615.8c

Annexin V SPECT imaging of phosphatidylserine expression in patients with dementia

Y. Lampl, M. Lorberboym, F. G. Blankenberg, M. Sadeh, R. Gilad

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33 Scopus citations

Abstract

The authors sought to use radiolabeled annexin V, a marker of phosphatidylserine expression, to image Alzheimer dementia (AD). Four of five patients with AD had multifocal cortical annexin V uptake, whereas all seven non-AD and six control patients had normal SPECT. The mean cortex/ cerebellar activity in patients with AD (1.4 ± 0.6) was higher than that of non-AD dementia patients (0.7 ± 0.2; p = 0.02). Radiolabeled annexin V may be useful for imaging AD.

Original language	English
Pages (from-to)	1253-1254
Number of pages	2
Journal	Neurology
Volume	66
Issue number	8
DOIs	https://doi.org/10.1212/01.wnl.0000208436.75615.8c
State	Published - Apr 2006
Externally published	Yes

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AB - The authors sought to use radiolabeled annexin V, a marker of phosphatidylserine expression, to image Alzheimer dementia (AD). Four of five patients with AD had multifocal cortical annexin V uptake, whereas all seven non-AD and six control patients had normal SPECT. The mean cortex/ cerebellar activity in patients with AD (1.4 ± 0.6) was higher than that of non-AD dementia patients (0.7 ± 0.2; p = 0.02). Radiolabeled annexin V may be useful for imaging AD.

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Annexin V SPECT imaging of phosphatidylserine expression in patients with dementia

Abstract

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