Animal models of myelofibrosis

Alessandro M. Vannucchi; Jean Luc Villeval; Orianne Wagner-Ballon; Paola Guglielmelli; Anna Rita Migliaccio

doi:10.1007/978-1-59745-285-4_73

Animal models of myelofibrosis

Alessandro M. Vannucchi
, Jean Luc Villeval
, Orianne Wagner-Ballon
, Paola Guglielmelli
, Anna Rita Migliaccio

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

The pathogenesis of idiopathic myelofibrosis has not yet been completely elucidated, but the availability of animal models of the disease has made it possible, in the past few years, to focus on the cells (megakaryocytes) and cytokines (transforming growth factor-β, among others) potentially involved. This review will deal with the two best characterized animal models (the TPO-overexpressing and the GATA-1^low mouse) as well as with the newest ones that have been developed following the identification of the JAK2 ^V617F and MPL ^W515K/L mutations in the human form of the disease. Each of these unique animal models conceivably represents an invaluable tool for further characterizing the disease mechanisms as well as for testing novel therapeutic agents.

Original language	English
Title of host publication	Source Book of Models for Biomedical Research
Publisher	Humana Press
Pages	713-723
Number of pages	11
ISBN (Print)	9781588299338
DOIs	https://doi.org/10.1007/978-1-59745-285-4_73
State	Published - 2008
Externally published	Yes

Keywords

Animal models
GATA-1
Megakaryocyte
Mpl
Myelofibrosis
Osteosclerosis
Transforming growth factor-β

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10.1007/978-1-59745-285-4_73

Cite this

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title = "Animal models of myelofibrosis",

abstract = "The pathogenesis of idiopathic myelofibrosis has not yet been completely elucidated, but the availability of animal models of the disease has made it possible, in the past few years, to focus on the cells (megakaryocytes) and cytokines (transforming growth factor-β, among others) potentially involved. This review will deal with the two best characterized animal models (the TPO-overexpressing and the GATA-1low mouse) as well as with the newest ones that have been developed following the identification of the JAK2 V617F and MPL W515K/L mutations in the human form of the disease. Each of these unique animal models conceivably represents an invaluable tool for further characterizing the disease mechanisms as well as for testing novel therapeutic agents.",

keywords = "Animal models, GATA-1, Megakaryocyte, Mpl, Myelofibrosis, Osteosclerosis, Transforming growth factor-β",

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AU - Vannucchi, Alessandro M.

AU - Villeval, Jean Luc

AU - Wagner-Ballon, Orianne

AU - Guglielmelli, Paola

AU - Migliaccio, Anna Rita

PY - 2008

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AB - The pathogenesis of idiopathic myelofibrosis has not yet been completely elucidated, but the availability of animal models of the disease has made it possible, in the past few years, to focus on the cells (megakaryocytes) and cytokines (transforming growth factor-β, among others) potentially involved. This review will deal with the two best characterized animal models (the TPO-overexpressing and the GATA-1low mouse) as well as with the newest ones that have been developed following the identification of the JAK2 V617F and MPL W515K/L mutations in the human form of the disease. Each of these unique animal models conceivably represents an invaluable tool for further characterizing the disease mechanisms as well as for testing novel therapeutic agents.

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Animal models of myelofibrosis

Abstract

Keywords

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