Animal Models of Multiple Neurotransmitter Interactions in Alzheimer's Disease

V. Haroutunian, W. Wallace, A. C. Santucci, K. L. Davis

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Alzheimer's disease (AD) represents one neurodegenerative disorder whose etiology remains unknown. Animal model systems for AD are further hampered by the absence of the tools necessary to duplicate some of the known neurodegenerative changes. For example, slow progressive neurodegeneration has been difficult to reproduce. The studies presented in this chapter were conducted to determine whether the neurochemical deficits noted in AD could produce some of the cognitive symptoms of AD in animals, and whether the cognitive deficits so produced would be amenable to pharmacological alleviation. Based on these investigations, the chapter shows that some of the neurochemical deficits noted in AD may be intimately linked to another hallmark of the AD brain, namely, the synthesis of β-amyloid precursor protein.

Original languageEnglish
Title of host publicationBrain and Memory
Subtitle of host publicationModulation and Mediation of Neuroplasticity
PublisherOxford University Press
ISBN (Electronic)9780199847877
ISBN (Print)9780195082944
StatePublished - 22 Mar 2012


  • Alzheimer's disease
  • Animal model
  • Cognitive deficits
  • Neurochemical deficits
  • Neurodegeneration
  • β-amyloid precursor protein


Dive into the research topics of 'Animal Models of Multiple Neurotransmitter Interactions in Alzheimer's Disease'. Together they form a unique fingerprint.

Cite this