Animal models of Epstein Barr virus infection

Cornelia Gujer, Bithi Chatterjee, Vanessa Landtwing, Ana Raykova, Donal McHugh, Christian Münz

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

Epstein Barr virus (EBV) was the first human tumor virus to be described. Despite its discovery now more than fifty years ago, immune control of this virus is still not very well understood and no vaccine is available. This knowledge gap is due in part to the lack of a preclinical small animal model which can faithfully recapitulate EBV infection and immune control, and would allow testing of EBV specific vaccine candidates. With the advent of mice with reconstituted human immune system compartments (HIS mice) during the past decade this is changing. We will discuss which aspects of EBV infection and its immune control can already be modeled in HIS mice, and which shortcomings still need to be overcome in order to recapitulate the immunobiology of oncogenic EBV infection.

Original languageEnglish
Pages (from-to)6-10
Number of pages5
JournalCurrent Opinion in Virology
Volume13
DOIs
StatePublished - 1 Aug 2015
Externally publishedYes

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