Animal models for studying the etiology and treatment of low back pain

Changgui Shi; Sujun Qiu; Scott M. Riester; Vaskar Das; Bingqian Zhu; Atiyayein A. Wallace; Andre J. van Wijnen; Fackson Mwale; James C. Iatridis; Daisuke Sakai; Gina Votta-Velis; Wen Yuan; Hee Jeong Im

doi:10.1002/jor.23741

Animal models for studying the etiology and treatment of low back pain

Changgui Shi, Sujun Qiu, Scott M. Riester, Vaskar Das, Bingqian Zhu, Atiyayein A. Wallace, Andre J. van Wijnen, Fackson Mwale, James C. Iatridis, Daisuke Sakai, Gina Votta-Velis, Wen Yuan, Hee Jeong Im

Research output: Contribution to journal › Review article › peer-review

45 Scopus citations

Abstract

Chronic low back pain is a major cause of disability and health care costs. Effective treatments are inadequate for many patients. Animal models are essential to further understanding of the pain mechanism and testing potential therapies. Currently, a number of preclinical models have been developed attempting to mimic aspects of clinical conditions that contribute to low back pain (LBP). This review focused on describing these animal models and the main behavioral tests for assessing pain in each model. Animal models of LBP can be divided into the following five categories: Discogenic LBP, radicular back pain, facet joint osteoarthritis back pain, muscle-induced LBP, and spontaneous occurring LBP models. These models are important not only for enhancing our knowledge of how LBP is generated, but also for the development of novel therapeutic regimens to treat LBP in patients.

Original language	English
Pages (from-to)	1305-1312
Number of pages	8
Journal	Journal of Orthopaedic Research
Volume	36
Issue number	5
DOIs	https://doi.org/10.1002/jor.23741
State	Published - May 2018

Keywords

animal model
discogenic pain
dorsal root ganglia
low back pain
pain assessment
spinal cord

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10.1002/jor.23741

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title = "Animal models for studying the etiology and treatment of low back pain",

abstract = "Chronic low back pain is a major cause of disability and health care costs. Effective treatments are inadequate for many patients. Animal models are essential to further understanding of the pain mechanism and testing potential therapies. Currently, a number of preclinical models have been developed attempting to mimic aspects of clinical conditions that contribute to low back pain (LBP). This review focused on describing these animal models and the main behavioral tests for assessing pain in each model. Animal models of LBP can be divided into the following five categories: Discogenic LBP, radicular back pain, facet joint osteoarthritis back pain, muscle-induced LBP, and spontaneous occurring LBP models. These models are important not only for enhancing our knowledge of how LBP is generated, but also for the development of novel therapeutic regimens to treat LBP in patients.",

keywords = "animal model, discogenic pain, dorsal root ganglia, low back pain, pain assessment, spinal cord",

author = "Changgui Shi and Sujun Qiu and Riester, {Scott M.} and Vaskar Das and Bingqian Zhu and Wallace, {Atiyayein A.} and {van Wijnen}, {Andre J.} and Fackson Mwale and Iatridis, {James C.} and Daisuke Sakai and Gina Votta-Velis and Wen Yuan and Im, {Hee Jeong}",

note = "Publisher Copyright: {\textcopyright} 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.",

year = "2018",

month = may,

doi = "10.1002/jor.23741",

language = "English",

volume = "36",

pages = "1305--1312",

journal = "Journal of Orthopaedic Research",

issn = "0736-0266",

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AU - Shi, Changgui

AU - Qiu, Sujun

AU - Riester, Scott M.

AU - Das, Vaskar

AU - Zhu, Bingqian

AU - Wallace, Atiyayein A.

AU - van Wijnen, Andre J.

AU - Mwale, Fackson

AU - Iatridis, James C.

AU - Sakai, Daisuke

AU - Votta-Velis, Gina

AU - Yuan, Wen

AU - Im, Hee Jeong

PY - 2018/5

Y1 - 2018/5

N2 - Chronic low back pain is a major cause of disability and health care costs. Effective treatments are inadequate for many patients. Animal models are essential to further understanding of the pain mechanism and testing potential therapies. Currently, a number of preclinical models have been developed attempting to mimic aspects of clinical conditions that contribute to low back pain (LBP). This review focused on describing these animal models and the main behavioral tests for assessing pain in each model. Animal models of LBP can be divided into the following five categories: Discogenic LBP, radicular back pain, facet joint osteoarthritis back pain, muscle-induced LBP, and spontaneous occurring LBP models. These models are important not only for enhancing our knowledge of how LBP is generated, but also for the development of novel therapeutic regimens to treat LBP in patients.

AB - Chronic low back pain is a major cause of disability and health care costs. Effective treatments are inadequate for many patients. Animal models are essential to further understanding of the pain mechanism and testing potential therapies. Currently, a number of preclinical models have been developed attempting to mimic aspects of clinical conditions that contribute to low back pain (LBP). This review focused on describing these animal models and the main behavioral tests for assessing pain in each model. Animal models of LBP can be divided into the following five categories: Discogenic LBP, radicular back pain, facet joint osteoarthritis back pain, muscle-induced LBP, and spontaneous occurring LBP models. These models are important not only for enhancing our knowledge of how LBP is generated, but also for the development of novel therapeutic regimens to treat LBP in patients.

KW - animal model

KW - discogenic pain

KW - dorsal root ganglia

KW - low back pain

KW - pain assessment

KW - spinal cord

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JO - Journal of Orthopaedic Research

JF - Journal of Orthopaedic Research

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Animal models for studying the etiology and treatment of low back pain

Abstract

Keywords

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