Animal models and hallucinogenic drugs

Alexey Kozlenkov; Javier González-Maeso

doi:10.1007/978-1-4614-4121-2_14

Animal models and hallucinogenic drugs

Alexey Kozlenkov, Javier González-Maeso

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

3 Scopus citations

Abstract

The neuropsychological effects of naturally occurring psychoactive substances have been recognized for millennia. Hallucinogens, which include naturally occurring chemicals, such as mescaline and psilocybin, as well as synthetic compounds, such as lysergic acid diethylamide (LSD), induce profound alterations of human consciousness, emotion, and cognition. The discovery of the hallucinogenic effects of LSD, and the observations that LSD and the endogenous neurotransmitter serotonin share chemical and pharmacological pro fi les, led to the suggestion that biogenic amines like serotonin were involved in the psychosis of mental disorders such as schizophrenia. Understanding the mechanism by which hallucinogens elicit unique neurobehavioral effects may open up new avenues in drug abuse research, as well as contributing to the understanding of the endogenous psychosis of psychiatric diseases. Here we summarize recent advances in our understanding of the molecular mechanism of action of hallucinogenic drugs, as well as fi ndings obtained in animal models.

Original language	English
Title of host publication	The Neuroscience of Hallucinations
Publisher	Springer New York
Pages	253-277
Number of pages	25
ISBN (Electronic)	9781461441212
ISBN (Print)	9781461441205
DOIs	https://doi.org/10.1007/978-1-4614-4121-2_14
State	Published - 1 Jan 2013

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Animal models and hallucinogenic drugs

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