Angle closure in younger patients

Brian M. Chang, Jeffrey M. Liebmann, Robert Ritch, Louis B. Cantor, James C. Bobrow, Allan J. Flach, Albert W. Biglan, William Tasman

Research output: Contribution to journalConference articlepeer-review

20 Scopus citations


Purpose: Angle-closure glaucoma is rare in children and young adults. Only scattered cases associated with specific clinical entities have been reported. We evaluated the findings in patients in our database aged 40 or younger with angle closure. Methods: Our database was searched for patients with angle closure who were 40 years old or younger. Data recorded included age at initial consultation; age at the time of diagnosis; gender; results of slit-lamp examination, gonioscopy, and ultrasound biomicroscopy (from 1993 onward); clinical diagnosis; and therapy. Patients with previous incisional surgery were excluded, as were patients with anterior chamber proliferative mechanisms leading to angle closure. Results: Sixty-seven patients (49 females, 18 males) met entry criteria. Mean age (±SD) at the time of consultation was 34.4 ± 9.4 years (range, 3-68 years). Diagnoses included plateau iris syndrome (35 patients), iridociliary cysts (8 patients), retinopathy of prematurity (7 patients), uveitis (5 patients), isolated nanophthalmos (3 patients), relative pupillary block (2 patients), Weill-Marchesani syndrome (3 patients), and I patient each with Marfan syndrome, miotic-induced angle closure, persistent hyperplastic primary vitreous, and idiopathic lens subluxation. Conclusion: The etiology of angle closure in young persons is different from that in the older population and is typically associated with structural or developmental ocular anomalies rather than relative pupillary block. Following laser iridotomy, these eyes should be monitored for recurrent angle closure and the need for additional laser or incisional surgical intervention.

Original languageEnglish
Pages (from-to)201-214
Number of pages14
JournalTransactions of the American Ophthalmological Society
StatePublished - 2002
Event138th annual meeting - Rochester, MN, United States
Duration: 19 May 200222 May 2002


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