Anergy to dinitrochlorobenzene and depression of T lymphocytes in Crohn's disease and ulcerative colitis

S. Meyers, D. B. Sachar, R. N. Taub, H. D. Janowitz

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Skin reactivity to dinitrochlorobenzene (DNCB) and levels of circulating T-lymphocytes were measured in 15 patients with ulcerative colitis, 15 patients with Crohn's disease, and 12 normal control subjects. Diminished reactivity to DNCB was demonstrated in 87% of patients with Crohn's disease (p < 0.001) and in 53% with ulcerative colitis (p < 0.02), as compared with only 8.5% of controls; anergy was more frequent in Crohn's disease than in ulcerative colitis (p < 0.05). Levels of circulating T-lymphocytes were also depressed in both Crohn's disease and ulcerative colitis (P < 0.001) as compared with controls, with the values lower in Crohn's disease than in ulcerative colitis (P < 0.02). There were no correlations of DNCB response with extent, duration, or severity of disease nor with T-cell levels within any patient group. These data provide further support for the concept that there is impairment of cell-mediated immunity among many patients with chronic inflammatory bowel disease, including both Crohn's disease and ulcerative colitis.

Original languageEnglish
Pages (from-to)911-915
Number of pages5
JournalGut
Volume17
Issue number11
DOIs
StatePublished - 1976
Externally publishedYes

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