TY - JOUR
T1 - Androgens up-regulate transcription of the notch inhibitor numb in C2C12 myoblasts via wnt/β-catenin signaling to t cell factor elements in the numb promoter
AU - Liu, Xin Hua
AU - Wu, Yong
AU - Yao, Shen
AU - Levine, Alice C.
AU - Kirschenbaum, Alexander
AU - Collier, Lauren
AU - Bauman, William A.
AU - Cardozo, Christopher P.
PY - 2013/6/21
Y1 - 2013/6/21
N2 - Background: Androgenic, Wnt, and Notch pathways regulate progenitor development through unknown mechanisms. Results: Up-regulation of Numb was blocked by Wnt inhibitors and required β-catenin. Nandrolone promoted binding of β-catenin to the Numb promoter and thereby increased its activity through Tcf bound at two consensus sites. Conclusion: Wnt/β-catenin signaling mediates nandrolone-induced Numb transcription. Significance: AR signaling regulates Wnt-Notch interaction via Numb, a newly identified Wnt target gene.
AB - Background: Androgenic, Wnt, and Notch pathways regulate progenitor development through unknown mechanisms. Results: Up-regulation of Numb was blocked by Wnt inhibitors and required β-catenin. Nandrolone promoted binding of β-catenin to the Numb promoter and thereby increased its activity through Tcf bound at two consensus sites. Conclusion: Wnt/β-catenin signaling mediates nandrolone-induced Numb transcription. Significance: AR signaling regulates Wnt-Notch interaction via Numb, a newly identified Wnt target gene.
UR - http://www.scopus.com/inward/record.url?scp=84880057379&partnerID=8YFLogxK
U2 - 10.1074/jbc.M113.478487
DO - 10.1074/jbc.M113.478487
M3 - Article
C2 - 23649620
AN - SCOPUS:84880057379
SN - 0021-9258
VL - 288
SP - 17990
EP - 17998
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 25
ER -